I can extract side effects

Chapter 137 Clinical Outcomes of Male Contraceptives

Regarding contraceptives, Weikang also did some research and understanding before he was willing to develop the project of male oral contraceptives.

Contraception has always been an old topic. Before the birth control pill was invented, although condoms could also prevent women from getting pregnant, the right to use condoms was more in the hands of men. So, women still endure the consequences of ongoing pregnancies.

It was not until the invention of norethindrone, a female oral contraceptive, that women truly had the initiative to control their birth and changed the choice of modern women's family and career.

It has been nearly 60 years since oral contraceptives for women were approved for marketing.

However, female contraceptives have many adverse reactions, such as headache, dizziness, breast pain, abdominal pain, nausea, etc., and are also prohibited for some patients with other diseases.

Moreover, despite the availability of a variety of contraceptive methods for women today, there are still as many as 85 million unintended pregnancies in women worldwide each year, about 50% of which end in induced abortion. In my country, the number of induced abortions is as high as 9.6 million cases per year.

Therefore, it is also of great significance for men to take contraceptive measures to prevent miscarriages caused by unwanted pregnancies.

Condoms and vasectomy are commonly used on the market to allow male contraception.

However, the reversibility of vasectomy is poor, and although condoms are very reversible, self-discipline is required to use, and it is easy to ignore this step when the situation is strong.

Therefore, for men who do not want to use condoms or vasectomy, male contraceptives undoubtedly have an important role to play.

The research and development of male contraceptives has also been going on for decades.

Male contraceptives mainly include hormonal contraceptives and non-hormonal contraceptives.

Hormonal contraceptives mainly act on the pituitary gland and the hypothalamus, thereby inhibiting the production of sperm in the body, reducing the number of sperm, and reaching a lack of sperm or even no sperm and infertility.

This is a rather troublesome thing. After all, men have a lot of sperm. It seems difficult to kill thousands of sperm without side effects, and to restore fertility quickly after stopping the drug. to things.

Therefore, hormonal contraceptives are generally expensive, inconvenient to use, and because of the mechanism of action, they are prone to decreased libido or sexual dysfunction, so further research is still needed to solve them.

Non-hormonal contraceptives may act as inhibitors at any point during sperm production, or may target sperm maturation, motility, or release. Because of its high specificity, low toxicity and side effects, and reversibility, it is favored by researchers.

At present, there are several non-hormonal contraceptives under research in the world, such as triptolide and gossypol, which are very promising, but they still need the support of large-scale clinical trials, and they have not yet been officially launched.

Some surveys on the acceptability of male contraceptives at home and abroad show that as long as it is safe and effective, more than half of the respondents are willing to accept and use oral contraceptives, and even more men hope to use this to control their own sperm.

Therefore, if the male contraceptive can be successfully developed, the market prospect should be quite broad.

So far, there are 18 officially recommended contraceptive methods, but none of them can completely achieve 100% contraceptive effect.

Contraceptives should meet three basic conditions: safe, effective, reversible, moderately priced, and easy to use.

Sanqing's male oral contraceptive perfectly meets the above requirements.

It works primarily in the early stages of sperm production, and its ingredients remove a key protein from sperm, so the sperm can't fertilize an egg, although they can still reach the woman's uterus.

And its side effects are very small, except for slight weight gain, it does not affect hormone levels, nor does it affect men's libido and sexual function.

What is even more surprising is that it is highly reversible and convenient. If you want to restore the ability to inseminate, you only need to stop taking the medicine, and it will return to normal after two weeks.

The effective rate can reach 99%, and the remaining 1% is attributed to the legendary force majeure.

After all, apart from God, it is estimated that no pharmaceutical company can guarantee 100% contraceptive efficacy.

According to animal experiments, after the mice took the new drug, they ate and mated as usual without any side effects.

The experimental reports of the first and second clinical phases also confirmed the safety and effectiveness of the drug.

This new drug is an oral tablet, one tablet per week for adult men, which is simpler and easier than injections, patches, and subcutaneous implants.

Since it does not prevent STDs, its target group is men in regular partners.

However, before the male contraceptive pill really enters the public eye, are men really ready?

Regarding this point, Wei Kang was not too sure.

The results can only be obtained after the male contraceptive pill is actually on the market.

After all, no matter how good the words are, if you want to know the real choice of men, you have to look at the sales.

Wei Kang looked at the clinical trial report and nodded with satisfaction.

"It's great. These drug testers should have spent a lot of money to invite them."

Wen Renlong chuckled: "Actually, it's okay. Most of them are middle-aged couples who are married and have children. They are the target customers of this drug, so it's not expensive to find them to try the drug."

"There are also some young people who have just married and don't want to have children for the time being. These young couples do have concerns about safety, so the cost of asking them to test drugs is indeed a bit higher."

"However, the word of mouth of our Sanqing is here, and we have also signed a high compensation agreement. Even though it took a lot of time, we managed to gather the number of people."

He was in high spirits, his face was full of light, and his expression revealed a kind of complacency, as if he was frantically wagging his tail and shouting, "Boss, look at how good I am, please praise me."

Wei Kang smiled slightly and praised: "Well done, you are the smartest person I have ever met in my life. This task was originally very difficult, but I didn't expect it to progress so fast in your hands. It's so amazing. It really is a natural talent. the scientist."

Wen Renlong waved his hands again and again: "Where, where, the boss, you are too much, I am not as good as you said, Lao Chen and Lao Tang are both better than me."

But his bright smile, his hands behind his back, and his standing posture with his head up and chest out, revealed the incomparable confidence in his bones.

Wei Kang showed a playful smile, and browsed the report again.

"Why don't you see your drug test data here?"

Wen Renlong's expression froze, his eyes rolled, and he touched his nose and replied, "My data is ordinary and nothing different, so I didn't mark it out."

Wei Kang laughed, and continued to ask with great interest.

"It's rare to have a drug tester in front of you, so I'll ask, do you have any special feelings after taking it?"

"Is there any discomfort? Will there be psychological hints? Will it affect your performance in bed?"

"If you choose voluntarily, would you rather take the pill yourself or let your partner take it? What are the reasons for doing so?"

"By the way, there is a key question I haven't asked yet."

"Do you have a regular partner?"

This series of questions caught Wen Renlong off guard. In his impression, Wei Kang was the kind of person who seldom talked about personal affairs. He never expected to suddenly burst out of curiosity and asked so many questions in one breath.

It's not true if he answers, and it's not true if he doesn't answer. Even if he answers, it's hard to say too much.

Immediately weeping and saying: "Boss, do you have so many questions? How about I go back and write you a drug test report?"

Wei Kang shook his head: "Forget it, I'll ask casually, and it's fine if you don't want to answer."

"It's just that I heard that you've always been single, so I'm a little curious."

Wen Renlong smiled awkwardly: "Well, boss, you are such a clean man, you are really a role model for my generation, but unfortunately I have been corrupted by the sugar-coated bullets of capitalism for too long, and I really can't be like you."

Wei Kang immediately understood it, and said with a smile: "Then you should be careful, this contraceptive pill can't prevent the spread of diseases."

Wen Renlong scratched his head: "Don't worry, I, Aaron, have been in love for many years, and nothing happened to me."

Wei Kang didn't ask any more questions. After reading the report, he really did a good job and was impeccable in every way.

"Thousands of people are required to test the drug in the third phase of the clinical trial, which is more difficult and takes longer. Are you confident?"

Wen Renlong said seriously: "I also asked the people who came to test the medicine, and the results they gave were very positive."

"Not only is it convenient to take, but it also has good effects and no side effects. It doesn't take much trouble to restore fertility, as long as you stop taking the medicine."

"The contraceptive measures they took before were basically women taking medicine. Now that the man is taking medicine, the man's enthusiasm is one aspect. The most important thing is that the woman is very motivated and has been urging the man to take the medicine on time, and even wants to continue. Participate in follow-up clinical trials."

"So this drug is very attractive to both husband and wife. To persuade people to try the drug, I think that in addition to starting with the man, we can also try to persuade the woman more, so that the effect can be achieved faster. I am still very confident in this aspect of."

Appreciation appeared in Wei Kang's eyes: "That's right, let's do it this way. I'm waiting for your clinical phase III report."

Wen Renlong left contentedly and returned to his office.

Just sat down, drank a saliva and still haven't swallowed it.

The door was pushed open violently and slammed against the wall with a bang.

Wen Renlong puffed his mouth, looked up, and was stunned, screaming inwardly.

Sheng Changya walked in angrily and slammed the door behind her.

She put her hands on her hips, stared at Wen Renlong with wide eyes, and let out a sneer.

"Tsk tsk, Brother Aaron, you did a good job, but you made me miserable."

Wen Renlong rolled his eyes and looked puzzled: "What's the matter? Sister Changya, why are you angry?"

He quickly got up and served Sheng Changya tea and water: "Don't be angry, it's my brother, what did I do wrong, did it make you angry?"

Sheng Changya rolled her eyes: "Don't do this to me, the girl I introduced to you last time, you two had a good talk, why did you suddenly dump her?"

The more she talked, the more angry she became: "You fucking pick up girls, can't you deal with the aftermath yourself? It's really annoying to make her come to me and cry to me every day. I don't want to take care of your crap, you can deal with her yourself."

Wen Renlong looked embarrassed and complained endlessly: "I didn't expect that, I paid enough money, I thought it was all right."

He laughed dryly: "I really didn't expect that she would look for you. It was my fault. I will treat you to dinner later and make amends."

Sheng Changya spat: "Hey, you scumbag, why did you just give up?"

Wen Renlong spread his hands and said: "Isn't it normal for people to share and reunite in a relationship? Besides, I agreed from the beginning that I couldn't get along with her, I had to get out of my heart, but in the end she couldn't afford it, blame me huh?"

Sheng Changya gritted her teeth and said, "You're so scumbag."

Wen Renlong sighed and said, "I didn't lie to her. I could tell right away that it was not suitable for her. I made it right from the beginning, and I didn't treat her badly. I gave her a lot of bags and gifts. It was her Think too much, can't bear the result."

"I don't even think about it. I, Aaron, is such a suave man, can a woman be tied up? Ha ha."

Sheng Changya said curiously: "You have high vision. He is also an 18th-line star after all. He wants to have good looks, a good figure, good temperament and conversation, and he is obedient to you. Why are you Are you disgusted like this?"

Wen Renlong said proudly: "You don't understand, what you said are all appearances, and to me they are just floating clouds."

"Only a woman with a mind as sexy as mine can have the honor of conquering me."

Sheng Changya looked like she was about to vomit: "Ouch, I can't stand your narcissist, why don't you look more handsome, earn a higher income, and make you look like a prodigal son in love."

She suddenly sneered and said, "Fortunately, I knew your virtue a long time ago. It's not easy to introduce this girl to you. You two are really scumbags and prostitutes. You are a perfect match. Don't worry, my sister will take care of it for you." .”

Wen Renlong's face darkened in an instant: "What do you mean? Is she not a good girl to co-operate with this girl?"

Sheng Changya suddenly let out a burst of laughter: "What do you think, with your reputation as a vagabond, I dare to introduce you to a good girl? Isn't that a lie?"

"I thought this girl had some tricks to take you down as a golden bachelor, but she is still a bit shallow, what a pity." She shook her head, as if she was very regretful.

Wen Renlong said with a stern face: "Then you are just acting in an angry way to settle accounts with me?"

Sheng Changya smiled: "Hey, it's not acting, it's watching a show, and my sister is just playing. Okay, enough playing, I'll go first."

Just as she turned around, the phone rang suddenly, she took it out and took a look, then turned and walked to Wen Renlong.

Shaking the phone in front of him, the word Xuanxuan was displayed on it, and it was Wen Renlong's ex-girlfriend.

Wen Renlong hurriedly waved his hands and said, "I won't answer."

Sheng Changya glared at him, then pressed the speakerphone: "Hey, baby, what's the matter?"

A sobbing voice came from a young girl on the phone: "Sister Chang Ya, I, I just found out that I am pregnant, what should I do, woo woo woo, I don't want to live anymore."

Sheng Changya was stunned for a moment, and couldn't help but look at Wen Renlong.

Wen Renlong was stunned for a while, then jumped up suddenly, and yelled into the phone: "What the hell is this? It has nothing to do with me, don't blame me."

The girl sobbed louder on the phone: "Aaron, why has nothing to do with you? We just broke up last week. We have been together for the past few months."

Wen Renlong interrupted her furiously: "Didn't you fucking say that you took the contraceptive pill?"

The girl paused and said in a low voice: "I lied to you, but I didn't eat it. I'm sorry, it's all because I love you so much. I really want to be with you."

Wen Renlong suddenly laughed: "Hehe, I didn't expect that, in fact, I lied to you too, I took contraceptive pills."

The girl was stunned for a moment: "???"

Wen Renlong said firmly: "Anyway, no matter whether you are pregnant or not, this child cannot be mine."

"That's it, contact me when you want to make a parent-child report."

With a snap, the phone hung up.

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