I can extract side effects

Xie Tianyin held his mobile phone and looked at the enthusiastic speeches of the group of friends, with a smile on the corner of his mouth.

Under the vigorous promotion of him and several branch managers, the trial operation of Rh-negative artificial blood in the Jiangnan area was very successful.

In order to popularize artificial blood as soon as possible, the group of friends rushed to participate in clinical trials for free.

The number of "help" calls he's had this week has dropped significantly.

In the past, at least ten blood donation requests were received every day, plus a series of tasks such as verifying information and calling volunteers, at least nearly two hundred calls were made a day.

But today, until the afternoon, he has not received any call from the hospital.

In the group that was filled with donation information in the past, everyone was discussing another matter.

"I just came back from the clinical trial. As a healthy person, I never thought that I would have a blood transfusion one day."

"It's a magical experience. I just donated 2 units of blood a month ago, and I feel that I have regained a little bit after participating in the trial."

"I transfused 50ml of artificial blood, and there was no adverse reaction."

"It wasn't long before I donated blood, so I received a unit of artificial red blood cells, and the feeling of weakness after donating blood disappeared."

"In fact, this is not a bad thing, it is beneficial to the body. It is said that athletes will draw their own blood during training and save it, and then reinfuse it before the competition. This can increase the number of red blood cells, allow the body to deliver more oxygen, and enhance endurance and exercise capacity. Get good grades."

"Haha, I didn't expect that I would also experience the effect of blood doping."

"Pfft, it's only a suspension penalty, and I have a complete set of operations."

"There are still a lot of growth factors in the blood plasma. I heard that there are rich people in Eagle Country. When they get older, they will spend millions of dollars to replace their whole body blood with the blood of young people on a regular basis, so as to maintain a youthful state."

"When I'm older, can I do the same thing? But I guess I can only use artificial blood."

"It's still safe to use industrial products such as artificial blood, at least there are no infectious diseases such as hepatitis."

"The number of people in Phase I and Phase II clinical trials is not too much. I went late and didn't sign up. It seems that I can only wait for the opening of Phase III trials."

"Actually, the clinical trial is not as scary as it is said on the Internet. Now I go for a review every two weeks to see if there are any adverse reactions."

"I still have to pay attention. During my physical examination, I saw someone who had an allergic reaction and a rash on their wrists when they received a subcutaneous injection."

"Whole blood is like this. There are too many and complicated components in plasma. If it is replaced with blood components such as red blood cells or platelets, there should be no big problem."

"By the way, do you know? The blood of Xinhua Hospital has been taken away in one pot."

"No wonder, when I went to prepare blood last week, I saw that the blood had disappeared."

"It is said that he refused to refund the patient's deposit, and then he was reported and directly entered the bureau."

"It deserves it, it's so expensive, it's like a steamed bun made of human blood."

"Thank goodness, these smoky guys are finally gone. Every time I go to donate blood, I always feel like they are fish on a chopping board, waiting for bids at any time."

"By the way, in the future, if someone artificially produces blood, do we still need to donate blood for free?"

When this question came up, everyone fell silent.

Everyone originally came together to donate blood for mutual aid, so if there is no need to donate blood in the future, is there still a need for this organization to exist?

"@集主, this matter was pushed forward by you alone, what do you think?" Someone started @谢天印.

Xie Tianyin chuckled, he had already expected this day, so he discussed this matter with the Provincial Blood Center.

After considering the words, Xie Tianyin slowly started typing.

"In fact, the free blood donation policy will not be abolished."

"The number of artificial blood is limited now, and it has not yet been officially mass-produced and launched. It can only be tested in the Jiangnan area."

"It may be several years before it can meet the needs of the whole country."

"Haishi now consumes thousands of units of blood every day. If it is extended to the whole country, it will be an astronomical figure."

"Therefore, I estimate that for a long time, artificial blood and free blood donation will be two tracks in parallel."

"If you have used artificial blood, you will know that the price of artificial blood is still quite expensive. According to the market price, a unit may cost thousands of yuan. If it is separated blood components, such as suspended red blood cells, the price It will be more expensive."

"And free blood only needs to pay a cost, mainly the cost of collection, testing, separation, and transportation. Under the above subsidy, a unit of 200ml is about 200 yuan, and the price is much cheaper."

"So artificial blood can only be used for acute blood transfusion and a large amount of surgical blood, and the problem of blood shortage should be solved first."

"For some people with limited financial conditions, they can donate blood for free at ordinary times, and they can ask their family members to donate blood when they need it. In this way, they can get cheap free blood with a blood donation certificate."

"In general, the two policies will go hand in hand for a period of time, which will not only solve the problem of blood shortage and crack down on illegal blood trading, but also allow people to retain their enthusiasm for free blood donation."

"Wait until the cost of artificial blood is completely reduced, and then consider whether to cancel the free blood donation system."

After reading his explanation, the group of friends all agreed with him, and they immediately expressed their opinions and discussed it one after another.

"I agree with the views of the group leader and the blood bank. Free blood donation is actually a good policy. It can be regarded as the mutual assistance of our low-level people. It's just that the publicity and implementation are not good enough. As a result, not many people respond, and the blood is not enough. It’s better to keep it.”

"Free blood donation is a public welfare behavior, and artificial blood is a market behavior. Each has its own advantages and can completely complement each other."

"The price of artificial blood is indeed relatively expensive. It may be affordable for major surgery, but it is difficult for patients with blood diseases who need long-term blood transfusion."

"Enterprises also need to make money to develop artificial blood. It is impossible to provide it to patients for free. Even the blood donated by us for free requires a series of costs for collection, transportation and storage. Let alone artificial blood, parallel regulation is the most realistic solution. .”

"I still plan to donate blood once a year. I'm used to doing this, and I still feel uncomfortable when I stop."

"In the past, we donated to people who had difficulty using blood. Now we donate to poor patients to make their lives easier. It's all about love, and there is no difference."

"Love brings us together, saving others is saving ourselves."

"Fortunately, no one will die from ischemia again."

"This is the meaning of our rare blood type alliance."

*****

Sanqing Headquarters, Plant No. 018, Biopharmaceutical Zone.

Ding Mian shuttled between the stainless steel culture tanks with a serious expression, and gave instructions to the staff beside him from time to time.

"The temperature of the culture environment must be strictly set at 37°C without any deviation. You can add some fresh medium every 3-4 days."

"Note that the density of stem cells must be high in order to proliferate quickly. If the number is still small after 3 days of culture, it means that the condition is not good. At this time, the density should be increased, and then continue to culture for a day or two, depending on the situation."

"Hematopoietic stem cells are suitable for growth in an acidic pH environment. Do not change the medium frequently. The nutrient solution must be strictly in accordance with the quantity. If the condition is not good, add a little more. The more acidic the condition, the greater the stem cell density, the better it will grow. .Attention, rather acid than alkali."

"The effect of the nutrient solution adjusted last time was not very good, and the value added was not fast enough. The ratio of LIF, β-mercaptoethanol, and L-glutamine was a bit wrong. I modified it again. When you prepare the next batch, press This ratio."

"Stem cells are relatively sensitive and easily affected by external stimuli. When changing the medium, it takes about a week to adapt. After adapting, it is best not to change it at will."

"Yes, yes." The production line supervisor held a notebook in his hand, quickly recorded all the operation steps and precautions, and asked a few questions from time to time.

"Theoretically speaking, the entire production process is perfect, and the output is strictly calculated according to the schedule, so there will be no major problems."

"After the artificial blood is fully cultured, it is filled into blood bags in batches of 400ml, and then samples are taken for routine blood tests. Everything is very normal. The results of bacterial and virus tests are also negative, and the transaminase tests are all normal. .”

"Well, you did a good job." Ding Mian nodded in approval while checking the inspection report.

"At present, this production line can already meet the demand for Rh-negative blood. But if it is to supply the blood demand of the whole country, it is far from enough."

After checking, Ding Mian shook his head and sighed.

The production line supervisor said with a wry smile: "Then how can it be? Our biopharmaceutical factory is already tight, and we can get a good one for artificial blood. Even if all the equipment is installed, I guess there are only six production lines."

Ding Mian smiled: "Anyway, if the production line of this factory is finished, my task will be considered complete. Then it will be up to you to find an outsourcer."

"So I try to fix all the operating procedures and data and make it a fool-like operation manual. In this way, the operators only need to operate the equipment step by step. When they are proficient, they can copy this set of replicas to any production. on-line."

"Yes, you are right." The production line supervisor flipped through the thick notebook and nodded repeatedly.

Behind him were several operators, all holding a small notebook, recording everything carefully.

The production process of artificial blood is very complicated, and they don't have much experience, so they can only practice as much as possible to become familiar with the whole operation process, especially the preparation of culture medium and nutrient solution, which is a technical task that requires extra care to complete.

Generally speaking, from the perspective of practical operation, the more complex the composition of the culture medium, the more comprehensive its functions will be, the more convenient it is to use, and the easier it is to raise stem cells.

The culture media used for hematopoietic stem cells are all purchased finished products, containing a variety of growth factors that promote cell proliferation, but it is still necessary to add some ingredients according to their own conditions to prepare the most perfect culture media.

"In fact, after we find the optimal ratio, we can customize the culture medium and nutrient solution according to the needs, so that it can be used immediately after thawing, which is convenient and quick, greatly reduces the operation process, improves production efficiency, and saves precious time."

The head of the production line made a suggestion. If the production is to be outsourced in the future, it is obvious that the deployment of these culture media also needs to be carefully optimized and customized by the supplier.

Ding Mian nodded: "That's natural."

"I heard that the trial of rare blood types in the Yangtze River Delta was very successful. Will there be no need to donate blood for free in the future?" Someone said excitedly.

Ding Mian shook his head and said, "It's not that easy, we've only just started."

Another employee pouted and said, "I don't think it's useless to donate blood for free. Regardless of whether blood donation is free or not, you still have to pay for it. It's better to buy it directly."

"Naive." Ding Mian sneered, "In the Eagle Country, free blood donation and paid blood donation coexist. Do you know where the blood product companies have the most blood collection points?"

"I don't know." Everyone shook their heads.

"Slums. Many poor people donate plasma twice a week and get more than $300 a month, and even $900 for their first donation, so they live on it. Of course, some vain people also rely on selling blood credit card."

"The place with the second most blood collection points is on the border between the Eagle Country and the Cactus Country. 90% of the donors come from the Cactus Country, because the cost of donating once is higher than their weekly salary, and this is their only source of income. "

Ding Mian continued, "This is pathetic enough, but what is even more frightening is the safety hazard of paid blood donation. Do you know why the Cherry Blossom Country changed from paid blood donation to unpaid blood donation?"

Everyone shook their heads again.

"Back then, the Ambassador of the Eagle Country had an accident in the Sakura Country. He suffered a hemorrhage and needed a blood transfusion, so he directly took more than a thousand milliliters of blood from the blood bank for transfusion. It didn't take long before he found out that he had hepatitis and other messy infections, such as HIV, anyway. He died a few months later."

"He walked peacefully, but the people of Sakura Country were not safe. All the citizens were completely blown up, because they discovered that there was a pile of mines buried in their blood bank, which were full of hidden dangers of bacteria and viruses, and even the ambassador was trapped. dead, let alone ordinary people."

"So we acted together from top to bottom, and finally started the free blood donation campaign, which resulted in the current results."

"So, paid blood donation is definitely a dead end. Only free blood donation can save the blood shortage."

"Of course, now that there is artificial blood, it is a more reasonable solution to run the two in parallel."

"It can be predicted that the mass production of artificial blood will be promoted to the whole country, and it will inevitably trigger a social change at that time."

Everyone nodded, their eyes filled with admiration, and they said, "Dr. Ding knows a lot more."

*****

Just when the artificial blood project was advancing steadily.

Wei Kang received a call from the space center.

The time for the rocket launch has been fixed and is scheduled for December 30.

From January 1st, he and Jian Lianyun will spend three days in the space station, and then return with the original spacecraft.

Since the two have already received three spaceflight trainings, they are now short of the final round.

On December 15th, the last 14 days of training before the rocket launch will officially begin.