I can extract side effects

"The first batch of clinical trial results have come out."

Ding Mian held a document in his hand, held it high in the air, and walked into Xue Shen's office excitedly.

Just as he was about to continue talking, he saw another person sitting in the office.

This is a young man in his twenties, the same age as him, sitting at his desk, with a simple and honest smile on his face, which makes people feel close.

Ding Mian got stuck immediately, forced out a smile and said: "There are other people here, please do your work first, I'll come back later."

"Don't, don't, they are all our own." Xue Shen quickly stood up and pushed him enthusiastically on another chair.

"This is my roommate Huang Qin, the person in charge of the animal and plant laboratory. He will be off work soon. He came to meet me for dinner, and we started chatting. You are all my buddies. It's rare to meet, so let's get to know each other."

Huang Qin immediately gave a thumbs up, smiling all over his face like a nympho fan meeting.

"You are the Ding God that Brother Xue often talks about. I have admired you for a long time. I have been looking forward to you for a long time. I have done a good job in scientific research, you are handsome, and you are so young and promising. I must meet you today." Please ask for advice and get some academic spirit."

Hearing what he said, Ding Mian was very happy in his heart, and quickly said modestly: "Where is that, in fact, I also heard Brother Xue mention you, he said that you are the most hardworking person he has ever seen, you really live up to your name, it is amazing admire."

The two boasted about each other's business, and soon hit it off, hooking shoulders and backs with enthusiasm, as good as brothers who have known each other for many years.

"Cough cough," Xue Shen coughed twice, and reminded: "Don't bother talking too much, what's the matter with the clinical trial results just mentioned?"

"Oh, this, the experimental results are very gratifying, I'll read you some data." Ding Mian opened the file in his hand and began to read.

"56 patients with acute renal failure from three medical institutions joined the clinical trial to conduct a comparative test of artificial kidney and conventional dialysis."

"Among them, 16 patients only received conventional continuous dialysis, 6 of them died due to various complications, 8 of them were transformed into chronic renal failure despite timely treatment, and only 2 of them were completely cured."

"Eighteen patients received 72 hours of artificial kidney treatment. Except for one elderly man who died of a serious illness, the others all improved and were converted to conventional treatment, and were soon cured and discharged."

"The remaining 22 patients had acute renal failure caused by uremia. They received artificial kidney treatment for up to a month, and their creatinine values ​​dropped by around 100. There was no death case."

"As for the long-term dialysis effect of the artificial kidney, we need to continue to look at it, but it should not be higher than the 20% annual mortality rate of conventional dialysis."

He glanced at Huang Qin, and considering that the other party might not know much about artificial kidneys, he explained thoughtfully.

"An important cause of death in routine dialysis is that the time interval between dialysis on weekends is longer, water and sodium retention, toxins and blood potassium accumulate in the body correspondingly, leading to acute sudden death."

"In addition, uremic toxins include water-soluble small molecule toxins, middle molecule toxins and protein-bound toxins. Conventional dialysis mainly uses the principle of diffusion and convection to remove metabolic waste, harmful substances and excess water, which can effectively remove low molecular and even medium Molecular toxins, but protein-bound toxins cannot be effectively removed, and a lot of toxins accumulate in the body after long-term use, which is also one of the reasons for the high chronic mortality."

"Our artificial kidney uses biological renal tubular cells, which achieve most of the real kidney function, can more efficiently remove middle molecules and protein-bound toxins, improve the quality of life of patients, and greatly reduce mortality."

"After the hemofiltration membrane is optimized, as long as it is replaced in time, there will be no hemolysis or thrombus."

"If all uremia patients are dialysised with artificial kidneys, I estimate that the mortality rate can be reduced to one-tenth, from 20% to 2% per year, which greatly prolongs the life of patients."

"Of course, this is just my guess, and everything has to be verified in the follow-up phase III clinical trials."

After Ding Mian finished speaking in one breath, Huang Qin was the first to applaud.

"God Ding deserves to be God Ding, awesome!"

Ding Mian chuckled, and asked curiously: "Brother, you are studying animals and plants, so what exactly do you study?"

Huang Qin thought for a while and said: "The main thing is to do various gene editing animals and plants, most of which are cooperated with external research institutes, institutions and companies. We develop genetic technology, they provide samples, and then carry out subsequent cultivation. If you have any needs, please give us feedback and we will improve.”

"That's about it. In fact, I'm not a serious laboratory, but a small department attached to the biological laboratory."

Having said that, he blinked ambiguously and smiled.

"Our laboratory has a subordinate farm, which is not far away. There are genetically modified pigs, cattle, sheep, chickens, ducks and so on. When you want to have a tooth-making festival, just tell me. I have a lot of fresh products. "

Xue Shen on the side immediately understood, and laughed: "I understand, I understand. I have long heard of your name as the canteen manager."

Ding Mian nodded, and asked again: "The devil's muscle pig in our cafeteria is produced by your farm, right?"

Huang Qin thought that the other party liked this meat and wanted to get some money from him, so he rolled his eyes, patted his chest and said.

"Brother, do you like this too? Good eyesight, to be honest, this is our most popular product. A batch has just been released, and only half a box is left. I still have some stock, I can pick it out for you A few dollars..."

Ding Mian interrupted him: "No, I want to ask how far has your gene editing technology in pigs progressed? Can you knock out the kidney development gene of pig embryos?"

Huang Qin was stunned for a moment, his brain froze, and he spoke after a while.

"Currently, only gene editing technology can be used to cut out retroviruses in pigs. This is already a great progress."

"I know that if the virus is not removed, pig hearts transplanted into humans will cause new infectious diseases. Indeed, this work has removed a big obstacle for pig organs to be transplanted into humans." Ding Mian deeply agrees nodded.

Huang Qin suddenly became excited: "I knew you were knowledgeable. Gene-editing pigs is actually one of my research and development directions. My idea is to use the latest gene-editing technology to transform the genes of pigs so that pigs can produce pigs that can be compared with humans." Compatible organs."

"Pigs are food for human beings, so as a source of organ transplantation, there are definitely no ethical issues. Pigs have a large number of litters, a short gestation period, and the size of their organs is very close to that of humans. From all aspects, they are very High-quality organ source."

"Many examples have confirmed that a part of a pig can be successfully used in humans and has high biocompatibility."

"Of course, there are still many obstacles to directly transplanting pig organs into humans, but the main problems are immune rejection, which can be solved by gene editing technology."

"I have also conducted some research on the pig genome in the past two years. I mainly want to knock out some genes in pig cells that are likely to cause rejection by the human immune system, and then cultivate them to see if I can cultivate pigs that can be transplanted. Pig organs."

"However, research in this area is still a bit difficult, and I may not be able to do it alone..."

Before he finished speaking, Ding Mian held his hand tightly, and two gleams shot out from his eyes.

"Brother Qin, this is your research on xenotransplantation, it coincides with my research direction."

"Excuse me, has your research on the pig genome produced any results?"

Huang Qin withdrew his hand quietly, and said with a dry smile: "Yes, there are, but I am studying the genes of the immune system of pigs, as well as the genes of meat quality and growth. I haven't studied organs such as the kidney in depth."

"But don't worry, the Academy of Agricultural Sciences is also at the forefront of research in this area. They have released the genome map of pigs. If you want to study kidney genes, there is no problem at all."

Ding Mian looked at him fixedly: "But I want you to study pig kidneys, what do you think?"

"Huh?" Huang Qin was stunned again, and said falteringly: "I'm working and studying at the same time, and I'm quite busy. I need to spare time to study this..."

Xue Shen suddenly patted him hard, winked, and said, "Qin, have you chosen your doctoral dissertation topic?"

Huang Qin scratched his head, subconsciously said: "I haven't thought about it yet, it's still early, I just graduated, how can I think of a doctoral dissertation, and I have to discuss this with my supervisor."

Xue Shen said decisively: "Listen to me, you choose the subject of pig xenotransplantation, which is absolutely high-end, absolutely cutting-edge, can produce great results, and..."

He pointed at Ding Mian, showed a treacherous smile, and said: "You want to study this topic, there is a ready-made labor, no, I mean a partner?"

Huang Qin's eyes widened instantly, he looked at Ding Mian, then at Xue Shen, his voice trembling: "Brother, can this work?"

Ding Mian was already deep in thought at this time. He was a little frustrated that the bioartificial kidney could not be implanted into the human body last time, and he was always thinking about continuing to study and solve the problem of artificial kidney transplantation into the human body.

Today, when Huang Qin talked about pig xenotransplantation, it was like a spark that instantly ignited a brainstorm in his mind.

He is now completely immersed in his own world, talking to himself and dancing.

"Boss Wei said it well, either don't do it, or make a big one to solve the problem completely."

"Since the problem of renal tubule death in the artificial kidney cannot be solved, then a kidney can be directly created and transplanted into the human body."

"You are right, editing and knocking out pig genes is no longer a big problem."

"The whole gene map of pigs is also available. We can completely compare the genes of pigs with those of humans, and then gradually modify a certain part of the genes of pigs, such as genes in immunity, to human genes."

"If the immune genes in pigs that are different from those in humans can be knocked out, the problem of biocompatibility between pigs and humans can be solved, and there will be no heterogeneous immunity and infection after transplantation."

"Theoretically speaking, this step is not too difficult, and the company's genetic laboratory can do it."

"But that's just the first step."

"The second step is to continue to use gene editing technology to knock out the kidneys or hearts of pigs, whatever, the developmental genes of any organ, whichever is easier to knock out first."

"So what do we get? A pig born without kidneys."

"Of course, this dysplastic pig is just an innocent blastocyst. At this point, we can proceed to the final step."

"Then, when everything was ready, we injected human stem cells into blastocysts that lacked genes for kidney development and allowed them to mature."

"Then, when the pig develops into an embryo, its kidneys will be completely developed from human stem cells."

"During the six months from pig growth to slaughter, a human kidney will mature in its body, waiting to be picked."

"If this 'organ planting' method can be successful, not only kidneys, hearts, but other human organs besides the brain can be produced from pigs."

"Absolutely fantastic surrogacy. Bravo!"

With a strange cry, Ding Mian ended this exciting speech. When he looked excitedly at Huang Qin and Xue Shen, he saw that the other party was looking at him with strange eyes.

Ding Mian touched his cheek: "What's wrong? Is there something on my face?"

Xue Shen looked at him worriedly, and hesitated to speak: "Xiao Ding, are you kidding yourself again?"

The expression on Huang Qin's face was very complicated, and he was fascinated for a while, and frowning and gnashing his teeth for a while, as if a fierce struggle was going on in his heart.

After a while, he said: "Ding Shen, your ideal is very beautiful, but if you want to realize it, I'm afraid it won't come to fruition in a few years."

Ding Mian was surprised and said: "Didn't I make it very clear? There are three steps in total, and each step has a specific research direction? Is this not realistic enough? It is already as simple as putting an elephant in the refrigerator. "

He looked at Huang Qin with strange eyes: "As for the time, it's not a big problem. It will definitely take a few years to figure it out. Are you still afraid that Mr. Wei won't give you the money?"

Huang Qin smiled wryly: "But if I choose this for my doctoral dissertation, I'm afraid I won't be able to graduate within ten years."

"That's it, that's definitely not possible." Ding Mian suddenly realized, he shook his head, and said very seriously.

"Then we have to hurry up. We must not delay it for too long. Ten years is definitely not enough. I think two or three years should be enough."

"Huh?" Huang Qin was completely stunned. He grabbed Ding Mian and wanted to roar twice to wake him up.

Haven't had time to speak yet.

Xue Shen spoke next to him.

He squeezed his throat and said leisurely.

"Qin, if this project is really successful, you will be a giant in the field of xenotransplantation. The academician will bow to you when he sees you. Think about it for yourself. Is it a bad topic or a paper? Or a stud, to be a great master who opened up the world?"

"This..." Huang Qin swallowed a mouthful of saliva with difficulty, grabbed Ding Mian's hands, and shrank back embarrassingly.

He patted Ding Mian's shoulder lightly, and smiled innocently: "Ding Shen, why is there dust on your shirt, come, let me pat it for you."

"Since Ding Shen is so confident, my old Huang is not a coward without courage."

"Isn't it because I was the only one studying this before? I'm used to fighting alone. Now that Ding Shen is joining me, I think it will definitely be successful."

"This is a strong alliance between the two of us. I can handle everything on pigs, and you can handle everything on stem cells. What do you think?"

The corners of Ding Mian's mouth curled up, his hands clenched into fists, and stretched out.

Although Huang Qin didn't know why, he followed suit and stretched out his fist.

The two fists touched lightly in the air, and then retracted immediately.

Only then did Ding Mian show a bright smile: "Hello, teammate."