I can extract side effects

Kunming, Sanqing Headquarters.

At nine o'clock in the evening, on the small road by the river, several figures were stretching their bodies, stretching their legs, and running panting.

Xue Shen is also one of them, but he is a bit older, over 30, runs slower and lasts for a shorter time.

After running for three to five hundred meters, he would stop and rest for a while, his chest heaved violently, gasping for breath, and his lungs felt as if they were being torn apart by a beast, which was extremely uncomfortable.

After finally running a thousand meters, he was sweating profusely, dizzy, and struggled to sit on the bench by the roadside, but couldn't get up.

"Xue Bo, your physique is not very good. You can't run after such a short distance? It seems that you need to exercise more at ordinary times."

The familiar colleague laughed and joked, then waved his hand, the wind was blowing under his feet, and he ran away in an instant.

"You... brat, you actually showed off in front of me."

Xue Shen was ashamed and annoyed, but he was too old to control his health, and he had neglected to exercise in recent years, working hard every day in the laboratory or in the office. Naturally, he was no match for a young man in his early 20s.

"No, I also want to run every day and night, exercise my body well, and don't fall behind others. My body is the capital of my work. I don't want to die suddenly while I'm doing it."

He comforted himself, adjusted his breathing slowly, and finally stood on the runway again.

In this way, stop and go, I finally ran 5 kilometers before ten o'clock.

When Xue Shen returned to the dormitory, he was sweating profusely, as if he had been fished out of the sink, but he was very happy.

I finally ran down today, and it didn't seem to be difficult. Although I was sweating, I felt strangely refreshed.

As long as you run every day and persevere, your body will definitely return to its youthful vigor.

He took a shower at the speed of light, lay on the bed, and fell asleep while scrolling through the industry news.

The next day, when the first ray of sunlight shone into the room in the morning, Xue Shen opened his eyes and jumped up happily.

Ah~

Unexpectedly, as soon as he stood up, he felt sore all over, especially when his legs stepped on the ground, it hurt like a knife.

Can't help but let out a heart-piercing scream!

"Ah~"

"Damn! It must be due to too little exercise, excessive use of the leg muscles in a short period of time, and the accumulation of lactic acid produced by the inability to tolerate the long-term anaerobic state, resulting in severe pain."

Xue Shen's mind turned, and the stored knowledge gushed out, and he instantly understood what was going on.

"Damn it, it looks like I have to rest in bed for a while." He complained incessantly, quickly searched on his phone, and followed the tips on the Internet to give himself a leg massage.

After a full ten minutes of pressing, the soreness in both legs was relieved a little, and I was finally able to get out of bed and walk around.

Although the two legs were still as heavy as if they had been filled with lead, and they felt a little numb from time to time, at least they didn't hurt so badly.

"Damn lactic acid, I just ran for a day, why did it accumulate so badly?"

He thought angrily: "No, I have to solve this problem, otherwise I won't be able to run at night in the future."

"I can't run for two days and rest for three days. That's useless. Besides, I'm not a professional athlete. It's impossible for me to run for a while and find a coach to guide me on how to do recovery training."

"Anaerobic exercise, lactic acid accumulation, anaerobic exercise, lactic acid accumulation..."

All the way to the laboratory, Xue Shen kept chanting these two words.

Until sitting at the desk, he suddenly had a flash of inspiration in his mind.

"By the way, since anaerobic exercise is prone to produce lactic acid, and the accumulation of lactic acid will cause muscle soreness."

"Then this is nothing more than a problem caused by insufficient oxygen supply in the body. As long as I solve this oxygen supply problem and provide sufficient oxygen to the body, won't it be completely solved?"

"The problem is discovered, so how to solve it?"

"When running, the body needs a lot of oxygen to support the movement of the muscles. This demand is fixed and cannot be changed. It can only be improved from other variables."

"It is known that my cardiopulmonary function is fixed. Unless the gene is mutated and becomes shark lung, there is not much room for improvement. If I want to adjust the breathing frequency to improve, I have to seek the help of a kinesiology expert. The process is too troublesome and time-consuming. It's been too long."

"So, assuming the volume of gas inhaled in a deep breath remains the same, how can we increase the oxygen content?"

"There seem to be two ways. One is to increase the oxygen content of the gas. I remember that there is a portable oxygen cylinder. See if I can buy one and wear it while running. It should increase the oxygen intake."

However, when Xue Shen remembered the scene where he was carrying an oxygen bottle and inhaling oxygen while running.

Another picture couldn't help but pop up in his mind.

Several colleagues surrounded him, looking at him strangely, looking up and down with malicious eyes, and mocking him.

"Hey, Director Xue is only in his early 30s, why is his body so weak?"

"Hahaha, you still bring oxygen cylinders for night running, Xue Bo, isn't that too exaggerated?"

"That's right, it's a bit premature, you look at a 70-year-old man dancing in the square for half an hour without blushing or panting."

"Oxygen inhalation? Did we move to the 5,000-meter plateau overnight?"

"Hahaha~"

Colleagues gathered more and more, and the laughter became more and more arrogant.

Even Mr. Wei was startled, casting a suspicious look over him.

"Xiao Xue, is your health so bad? You're too tired, you should pay attention to rest."

"You don't need to worry about work. I think Xiao Zhou in your group is also very capable. Why don't you leave it to him first, and then you go home and rest for half a year?"

"What? Are you in good health? Then why do you take oxygen while running? Is there some illness that is hidden from me?"

Such a social death scene instantly made Xue Shen tremble all over, and immediately dispelled the idea of ​​inhaling oxygen in public.

"No, if you want to inhale oxygen, you can only inhale in advance and then run, otherwise you will definitely be laughed at by your colleagues."

"But it's useless to inhale in advance. The ability of hemoglobin to carry oxygen is limited."

"Unless..." His eyes suddenly lit up, and he stood up abruptly.

"Unless I can find a nanoparticle that has an oxygen-carrying capacity that far exceeds that of hemoglobin, even daily breathing can provide sufficient oxygen to meet the oxygen demand of muscle tissue, so that my body will never feel tired again."

"This is the solution once and for all!"

"And I'm very tall, and I can't tell from my appearance at all. My colleagues will only think that I have great physical fitness, awesome Plus."

Thinking of myself galloping on the runway, riding the dust, leaving only an elegant and blurred back.

Colleagues were left far behind, they could only exclaim and cast admiring glances.

Xue Shen felt itchy all of a sudden, wishing he could research this miraculous nanoparticle right away, and give himself a tube on the spot.

"Fortunately, nanoparticles are my field of research, and there are quite a few substances with strong oxygen-carrying capacity. I will study hard and the difficulty should not be too great."

He turned on the computer excitedly and began to delve into the relevant literature.

This research immediately fascinated me.

Time flies, the sky outside the window gradually darkens, and the lights in the room automatically turn on.

"After reading the information for a day, I gained a lot."

"Now the research on biomimetic nanomaterials for oxygen delivery in the body is quite popular. I read a lot of literature and finally got a clue."

Xue Shen got up from the computer, stretched slowly, came to the window, gazed into the distance, lost in thought.

The blood of the human body is very hard. It not only transports various components necessary for the body, but also transports a large amount of oxygen needed for survival.

After all, the human body obtains the energy necessary for the body through redox reactions, and oxygen is the lifeline of the human body.

Elaborately designed red blood cells exist for the task of 'delivering oxygen'.

To make themselves as efficient as possible, red blood cells forgo all the components of traditional cells and are made almost entirely of hemoglobin.

A red blood cell contains 250,000 hemoglobin molecules, and each hemoglobin with a diameter of 5.5 nanometers has 4 slots on it, which can accurately carry four oxygen molecules.

In essence, red blood cells are a container that holds oxygen in it and transports it to all parts of the body.

It does not use oxygen itself, but uses glucose for energy needs.

However, hemoglobin also has a deficiency, that is, its preference for carbon monoxide is much higher than that of oxygen.

If carbon monoxide is present, the hemoglobin packs it off like a passenger on a rush hour train and leaves the oxygen on the platform, which is how carbon monoxide suffocates people.

At the same time, red blood cells use nitric oxide as a signaling molecule, which basically determines how much blood is distributed to which parts as the body's needs change at different times.

For example, a sufficient amount of blood is provided to the stomach after a meal to aid in digestion, so the brain generally feels sleepy after a meal, which is caused by insufficient blood supply to the brain.

At normal altitudes, red blood cells occupy 40% of the blood volume. This large and regularly operating system can normally meet the body's oxygen needs.

Of course, under abnormal circumstances, there will definitely be some accidents.

For example, if you go to a high-altitude area, your body will work overtime like a factory to produce a large number of red blood cells and increase the oxygen transport capacity of the blood.

In this way, after staying on the plateau for a period of time, the proportion of red blood cells in the body will increase by about half.

Such a high red blood cell content makes the blood viscous and sluggish, the pumping pressure of the heart increases sharply, the lips begin to turn purple, and the fingers are as thick as a mallet, thus suffering from a special disease.

But as long as you move to a lower altitude, the problem will disappear.

Of course, there are more problems like excessive exercise leading to lactic acid accumulation.

The lack of red blood cells leads to insufficient oxygen supply in the body, which is also the main cause of anemia.

If it is possible to produce a nanoparticle that is stronger than the oxygen transport capacity of red blood cells, in the case of an urgent need for a large amount of oxygen, it can be infused into the body in a short period of time, and then excreted through metabolism after use.

Not only can it solve the problem of insufficient oxygen during exercise, reduce the damage of anaerobic exercise, but also treat some altitude sickness.

Even, if it can be used for a long time, it can also be used to treat anemic diseases.

Thinking of this, Xue Shen's eyes suddenly lit up.

He started researching this, mainly for personal interest, but didn't think too much about it.

However, if you can solve individual problems, you can treat more patients.

Wouldn't it be possible to combine personal interests with company interests?

In other words, it is possible to use public equipment for private use, use the company's projects to benefit yourself, and benefit patients by the way, making a lot of money.

For the three parties, they have all gained a lot, and it is simply a win.

This may be the happiness of being a scientist.

Xue Shen thought complacently, and made a quick decision in his heart.

He quickly returned to the computer, his hands flying over the keyboard, and quickly wrote a simple project report.

Feasibility report on a biomimetic nanomaterial for oxygen delivery in vivo

I wrote a pass eloquently and submitted it.

"Okay, just wait a few days for the boss to approve it, and then we can start it."

"This is a small project. There are already many research results in academia, but there are no commercial products yet."

"Anyway, I don't have any big projects right now. Why don't I study this well? The prospects are still very bright."

"The most important thing is that I can be the first to enjoy any research results, no, try them out."

When Xue Shen thought of this, the corners of his mouth couldn't help curling up, and he began to laugh.

He turned off the computer, prepared to eat in the cafeteria, and then went back to continue his research.

However, just after taking two steps, the familiar soreness hit again.

"Your sister, why isn't it better? No, it's too uncomfortable. The project research must be done quickly."

Xue Shen cursed and limped out of the office.

The next day, after a night of rest, he finally felt better.

My waist is no longer sore, and my legs are no longer painful, but my thighs are still a little numb.

But it's not a big problem. If you rest for another day, you will definitely be able to fully recover.

After the routine work in the morning, suddenly a system notification was received in the mailbox.

"Your project approval request has been approved, please check it as soon as possible."

Xue Shen was overjoyed immediately: "The boss approved it so quickly? This is really fast."

Although he felt that the project would be fine and would not be rejected, Wei Kang's speed was beyond his expectations.

After glancing at the reply, he found that the boss was very appreciative of his idea, so he couldn't help showing a smile.

"Great. The next step is to select a few materials, and then simulate and optimize them on the computer."

"Wait until the results come out, and then do experiments to verify and see if there is any gain."

"There are many types of specific nano-oxygen carrier materials. In this regard, hemoglobin-like oxygen carriers and perfluorinated compound-like oxygen carriers are two of the more popular types."

"Hemoglobin-like oxygen carriers have two disadvantages. One is that it contains heme molecules, which will cause autooxidative damage to the body. The two hemoglobin and oxygen molecules are reversibly chemically combined, so they cannot release all dissolved oxygen to surrounding tissues. The efficiency of oxygen delivery is relatively high. Low."

"In comparison, perfluorinated compounds and oxygen are purely physically dissolved. With the same amount of dissolved oxygen, the released oxygen is 4 times higher than that of hemoglobin. Therefore, the ability to carry oxygen and release oxygen is very superior, and the tissue compatibility and safety are also good. have high clinical potential."

"Perfluorocarbon is a good choice. The hydrogen atoms are partially replaced by fluorine atoms. It is chemically inert and relatively safe. The dissolved oxygen is about 40-50vol%. Under the same oxygen partial pressure, the oxygen carrying capacity is that of water. and plasma 20-25 times."

"In addition, it also has the ability to dissolve carbon dioxide, which can take away the carbon dioxide produced by the aerobic respiration of tissue cells and the waste products produced by metabolism."

"At present, this substance does not have much clinical application. It is mainly used for blood substitutes, organ preservation perfusion fluids, etc., and there is still great development prospects."

"Of course, 20 times the oxygen-carrying capacity is still not enough. The molecular formula and nanostructure must be greatly improved, and the preparation method of the nanoemulsion must also be carefully designed to adapt to industrial mass production."

Xue Shen stared at the screen intently, immersed himself in it, and entered a state of ecstasy.