I can extract side effects

"Your condition has worsened again, and it looks a little bad."

When Ma Jun returned to Kunming City, after meeting Jian Lianyun, his heart was suspended in the air by the other party's first words.

"The walking posture has become more rigid. Do you need the support of your family to walk?"

"Well, you sit down first and let me check."

He obediently sat on the chair, accepting the doctor's examination.

Jian Lianyun does not tie her hair in a ponytail now, but simply pulls her hair behind her head. With her age, her demeanor has become more stable. When her expression is serious, she still has the aura of a department director, and her deterrent effect on patients is top-notch.

She picked up a small percussion hammer shaped like a compass, tapped lightly on the tendons in his hands and feet, and asked a series of questions at the same time.

"Can the feet be lifted? Can the fingers move?"

"Come on, swallow your saliva, how is your breathing, do you feel strenuous?"

Seeing that the patients answered one by one, and their articulate words were still clear, she showed a thoughtful expression, sat back in the chair and began to update the medical records.

"Director Jian, I heard that there is a special medicine for ALS? When can I start treatment?"

Ma Jun was worried. He heard that Sanqing's clinical programs were very popular. Although he signed up, he didn't know if he could be selected.

Jian Jianyun smiled and explained patiently: "Don't worry, since you have been notified, I must have seen your case and think it meets the requirements."

"This is a Phase I clinical trial. We have 30 places, and we mainly select early and mid-stage patients from Phase I to Phase III."

"Because ALS progresses rapidly and the patient's survival time is not long, the clinical focus is mainly on controlling the disease in stages I, II, and III, maintaining and restoring neurological function as much as possible, and delaying the time to reach the advanced stage of the disease."

"Stage IV and V patients are already in the advanced stage of the disease and are not suitable for clinical trials of this drug."

"The best period of stem cell therapy for ALS is in the early stage. In the late stage, lesions occur in both the brain and the brainstem, and it is still difficult to treat."

Ma Jun was overjoyed immediately: "Then I'm in the early stage, so I should still be saved."

"You were originally at stage II, but now there is a tendency to develop into stage III, so you need to be treated with medication as soon as possible."

Jian Jianyun handed over a document: "This is the consent form. After signing, go to the medical examination, and then extract the cells. After receiving the notification, you can come and be admitted to the hospital."

"Will you continue to wait? How long will it take?"

Ma Jun was a little disappointed when he heard the news. After hearing the news, he wished he could live in the clinical building that afternoon and start treatment immediately.

"Because you need to use your epidermal cells for culture to get suitable stem cells for follow-up treatment."

Jian Lianyun reassured: "About a week or so, for 30 people, a week's recovery is considered fast."

Only then did Ma Jun feel relieved, signed his name with difficulty, and went to another room accompanied by his family.

First, there was a routine physical examination. After all aspects met the requirements, the nurse took out a cotton swab, fiddled with it in his open mouth, and put it into a sealed test tube.

"That's enough? Don't you need to puncture a spine to get the bone marrow?"

"I heard that there are only stem cells in the spinal cord? You can get stem cells out of your mouth?"

Ma Jun showed a surprised expression. After learning about this, he immediately asked his son to check some relevant information on the Internet, and he thought he knew something about stem cell therapy.

Didn't everyone say that stem cells need a spinal tap before they can be taken out?

Why is it so easy here, just a few random gestures with the mouth, and it's over?

Is it such a fool?

Looking left and right, it feels a bit unreliable.

The nurse showed a clear expression: "Master, don't worry, we do stem cell differentiation, we only need your oral mucosa cells, no need for spinal cord puncture."

She shook the test tube and chuckled: "Don't look at just a cotton swab in the test tube, Sanqing only needs this little bit, and it can turn it into stem cells and treat your illness."

"Wow, amazing, this is the legendary high technology!" Ma Jun was shocked, feeling the shock of the mighty power of science and technology.

Although I have always heard about stem cells and other high-tech, and I know that this thing is very high-end, but I didn't realize how outrageous it was until I was there.

Just messing around in the mouth, taking some oral mucosal cells, can it become a panacea for ALS?

What's the difference between this and a fairy? It's too amazing.

His simple mind was instantly filled with admiration for Sanqing Medical Technology.

The son was also on the side, his eyes were as big as copper bells, and his eyes were full of shock and admiration.

"Dad, Sanqing really deserves its reputation, it's really awesome."

"Since the nurse said so, you can wait in peace."

The two went home excitedly and waited, which inevitably caused a lot of trouble in the patient group.

A week later, he received the notification as expected, and immediately rushed to the clinical building of the hospital with the luggage he had packed earlier.

Here, he will stay for a whole month.

It's exciting just thinking about it!

After waving goodbye to his family, Ma Jun changed into a clean blue and white striped hospital gown, followed the signs between the floors, and walked to his ward with a curious expression on his face.

There were already five or six patients sitting there, all younger than me, in their forties, which is also the age group with a high incidence of ALS.

Ma Jun glanced, and suddenly saw a young man in his early 30s, and was immediately surprised.

The others obviously had the same idea, and they were surrounding the young man, asking questions in one go.

"Young man, what's your name? Why did you get this disease at such a young age?"

"That's right, isn't it more common at the age of 40?"

"How can you get sick at 30? It's unscientific."

"My name is Wang Ping. Hehe, I don't know if it's scientific or not. Maybe this is fate."

Wang Ping scratched his head with a helpless expression.

He didn't know how he got this disease. Apart from the arrangement of fate, there was no other explanation.

However, he felt that getting this disease was a blessing in disguise. Not only did he find true love, but he also had a cure before he burped. It was really shit luck.

"I have to buy a few lottery tickets when I leave the hospital, maybe I can win a big prize."

He thought happily in his heart, he got terminally ill without 30, the despair and depression of dying soon.

Ma Jun didn't care about his age, but seized the opportunity and asked curiously.

"Do you understand this stem cell therapy? What's going on? Is it reliable?"

Patient friends, look at me and I look at you, all shaking their heads.

"I don't know, but it looks like it's inexplicably powerful."

Wang Ping coughed lightly, and interjected, "I checked the information, and I have a certain understanding of it."

He has studied in university and is no stranger to the concept of stem cells. After searching the Internet, he found some relevant information.

Now I have done a science popularization for everyone.

"This stem cell is different from ordinary cells. It is like a monkey grandchild, which can change in ever-changing ways."

"Oh, I understand, seventy-two changes, right? I understand!"

Several middle-aged people nodded repeatedly, showing expressions of sudden realization.

"Sanqing has a special method, just like Tang Seng's magic spell, he can change his grandson into whatever he wants, so they can turn any cell in your body into a specific type of cell called a neuron cell .”

"The disease in our body is that the neuron cells in the spinal cord are damaged. Sanqing injects the stem cells, and then recites the magic spell, which can turn the stem cells into neuron cells and repair the damaged nerves. This is almost the way to cure the disease."

"Oh, I understand too well." Ma Jun was excited and slapped his thigh suddenly.

"Sanqing is the Jade Emperor, who sent Tang Seng to control the stem cells of Monkey Sun, who entered our spinal cord and killed all the monsters."

"Then the great sage transformed into thousands of monkey grandchildren with a handful of monkey hair, filling up all the injuries in our spinal cords, and naturally cured the disease."

"Brothers, I understand this way, right?"

The others immediately showed expressions of "I understand" and cheered.

"Brother is awesome, I can understand after explaining this way."

"The co-author ancestor has already written it in the book."

"Sure enough, no matter what is new, it cannot be separated from the old methods of the ancestors."

"Huh? Can you still explain it like this?" Wang Ping was dumbfounded for a moment. In fact, he half-understood.

I was already outrageous, but I never thought that these uncles were even more outrageous than myself.

After a lot of rambling, he was able to be logical and self-consistent, and explained the treatment process in such an easy-to-understand manner that people didn't understand it and were convinced.

Seeing that he was going off topic for a long time, for a moment, he didn't know whether he was right or not, so he could only shut up.

Soon, this set of rhetoric spread among the patients participating in the clinic, and was well received by the masses.

The next day, 30 volunteers lined up one by one after breakfast to receive stem cell therapy.

There are also 5 healthy people who are not sick. They participated in clinical trials, mainly because they received money and sacrificed their lives to test the safety of stem cells in normal people.

This time, Ma Jun finally experienced the never-forgotten intrathecal injection of the spinal cord.

As soon as he lay on his side on the bed, he saw a doctor in a white coat come in and take out a long needle from the refrigerator.

Seeing the 10-centimeter-long thin needle approaching in front of him, he couldn't help but tremble all over.

After closing his eyes and holding on to finish the injection, his bones felt a little weak.

I can only feel a cool breath flowing in the spine along with the cerebrospinal fluid, circulating to various lesions.

After the intrathecal injection, he lay flat for half an hour according to the doctor's instructions. Ma Jun got up without feeling uncomfortable, but his old face was slightly red, and he had a serious psychological shadow from the 10 cm long needle.

"This is too scary. Such a long needle didn't pierce me right?"

"One month, I have to be stabbed every day, it's terrible."

He shivered a little when he thought of the thin and long needle that looked like an iron pick, which he had to use every day.

After slowly returning to the ward, everyone discussed their feelings.

"How are you feeling?"

"It's fine, I don't feel anything."

"Why do I feel more numb all over my body?"

"It may be that the needle is too long, and it has a psychological effect."

"On the first day, it must have not worked."

"That's right, there should be a response in a few days."

The patients discussed cheerfully with one sentence for you and one sentence for me, showing strong confidence in their tone.

The facts also supported their conjecture. At least after the follow-up injection, no one showed any adverse reactions. In terms of safety, it was considered a preliminary pass.

A week later, someone already felt the difference.

"Haha, it's really effective. I called my wife and daughter today and talked for half an hour without stopping. I used to be exhausted after talking intermittently for five minutes."

A patient happily shared his new discovery with the group.

"Me too, squatting is not so strenuous today, and I feel that my legs have strength again."

Ma Jun nodded with a serious face. He had noticed it in the past two days, and he hadn't had time to tell everyone that it didn't seem to be his own illusion.

"Hands, my hands, I finally stopped shaking when holding the glass while drinking water, and now no one will say that I am epileptic." Another patient shook the empty water glass up and down, shouting excitedly.

"I can actually climb the stairs, do you believe it? Although I have only climbed one floor, it is still a huge improvement." Wang Ping joined in happily.

After some discussion, everyone's condition improved more or less.

Muscle strength, fasciculations all improved, and speech and swallowing improved.

After the examination at the doctor's place the next day, more accurate results were obtained.

The electromyogram showed changes, the amplitude of compound muscle action potential improved, and the overall improvement was obvious.

As for the nerve repair in the spinal cord, because the time is too short, it is temporarily not obvious on the CT image.

Such a result, like a shot of cardiac stimulant, penetrated into the hearts of the patients.

Everyone rejoiced, feeling that a complete cure was at hand.

In the following treatment, 3-5 cases of low-grade fever and bone pain appeared one after another.

One patient had mild pain in the sacrum and coccygeal bone, and several patients had elevated body temperature, which lasted for 24-36 hours and recovered without special treatment.

Therefore, it did not cause panic in the patients, but everyone was relieved, and felt that it was normal to have some adverse reactions.

After half a month, the condition of all patients has been significantly improved.

Breathing and chewing functions have all returned to normal, and motor functions have also greatly improved.

Everyone is no longer weak in limbs. After some rehabilitation exercises, those who are seriously ill can walk freely without crutches, and those who are lighter can lift their legs and climb stairs.

The hand ability has also recovered by 70% or 80%. Daily brushing teeth, drinking water, writing with a pen, and typing on the screen are all fine.

It's just that the strength of the upper limbs has not recovered completely enough, and I don't have the strength to lift heavy objects, and changing the bucket of water from the drinking fountain is a bit choking.

However, not being able to move the vat of mineral water does not affect life, and everyone is still very happy.

One month later, all the patients who participated in the treatment were able to speak, dress, walk, and hygienic abilities were no different from normal people.

The muscle strength of the upper limbs has also increased, and the bottled water can be moved.

On the day they discovered this, the patients jumped up and down, full of energy, and changed the drinking fountains in every ward, even the infirmary and the nurse's station.

The MRI images also showed detailed distribution of spinal cord nerves. The axons and myelin sheaths of the damaged motor neurons had regrown, no different from normal nerve cells.

At this point, it can finally be confirmed that the Phase I clinical trial has been a great success.

There is finally a cure for ALS in the early and middle stages.

Time passed, and the day came when I was discharged from the hospital.

Every patient was smiling and walked out briskly, showing no signs of ALS at all.

They also carried their luggage one by one, saying that they would not let their family members do it for them, claiming that they wanted to experience the long-lost weight-bearing pleasure.

When they walked to the gate of the hospital, suddenly, everyone paused spontaneously.

As if blessed to the soul, Qiqi turned around.

Facing the direction of the clinical building, he bowed deeply.