I can extract side effects

Ridian, Royal Academy of Sciences, Nobel Committee.

In the gorgeous dome hall, a group of experts and scholars are holding a meeting to discuss one thing.

"That Wei Kang, who was blocked by us, actually set up an award named after his surname, to give awards to scholars in the basic field."

"I heard that each bonus is 3 million US dollars, twice as much as ours." Someone couldn't help but sigh.

"The bonus of 15 million US dollars per year is really shocking and enough to make people's hearts beat."

"So what, how can the holy grail of science be corrupted by money, and how can a Chinese pheasant award be compared with the Nobel Prize."

"Hehe, don't you know? Sanqing Group's organ planting technology has already had hundreds of clinical cases, which has brought him a huge global reputation. In the future, we will depend on him for organ transplantation." complexion."

A middle-aged scholar wearing glasses sneered: "Such an achievement cannot win the Nobel Prize because it comes from Sanqing. Do you think this affects the reputation of Sanqing or the reputation of the Nobel Prize?"

Another old man with white beard and hair showed a thoughtful expression.

"In the past few years, the Sanqing Group has achieved outstanding research results in biology and medicine, but their best scientists have missed the Nobel Prize and the highest academic honor."

"Weiss Science Award, this is to compensate them in terms of money and reputation."

"It just so happens that the great reputation brought about by the organ implantation technology can also be used to push this award to the highest hall in the academic world."

"This is digging our roots." An expert had a solemn face, with worry in his eyes.

"Organ implantation technology is the holy grail of biology. If it can win the Nobel Prize, it is the honor of the Nobel Prize. If it can't, it will put the Nobel Prize on the pillar of shame."

Someone sighed and said, "Is it because of the prize money of more than one million yuan that the Nobel Prize has its current status?"

"No, it's because we can always get rid of all prejudice, try to be as fair as possible, and present awards to the most shining human stars."

"Those great scientists do not need the recognition of the Nobel Prize. On the contrary, it is the Nobel Prize that needs their recognition."

"In fact, based on their achievements, whether they won an award or not, it does not affect the honor they have."

"Even if Einstein did not win the Nobel Prize, he is still the discoverer of the theory of relativity and one of the greatest scientists in history."

"Newton did not win the Nobel Prize, which does not affect his great achievements."

"Maybe, we did something wrong at the beginning, and we shouldn't exclude people from Sanqing."

Hearing this, the experts present looked at each other in blank dismay, all showing a hint of embarrassment.

However, there are also people who hold on and are unwilling to admit their mistakes.

An old lady in a fancy hat said haughtily, "I don't regret the decision I've made."

"Science must always serve mankind. No matter how great a scientist is, he cannot turn against mankind and become a racist."

"Besides, Weikang has intensified since then, and even founded a journal of their own, and their employees only contribute to their own journal, which is simply against us."

"Such a person who is self-confident, has no open mind, and is still obsessed with obsession, is not worthy of being a Nobel Prize winner."

"I only regret that I didn't recognize Wei Kang's true face back then and voted for him."

"I promise I will never make this mistake again."

However, after she said these outrageous words, they were not recognized by all the experts on the scene as before.

Except for a few people who nodded their heads in agreement, the others didn't say a word, and there was even a hint of coldness in their eyes.

The entire conference hall suddenly fell into an embarrassing silence.

"It's a pity that such a great figure leading the times has finally stood on the opposite side of us."

"Time and fate, when the stars in the east are shining in the sky, we can only look up from afar, unable to witness this moment."

Someone sighed insignificantly, as if regretting something.

Almost suddenly, the atmosphere inexplicably became heavy.

*****

On the other side of the distant earth, the headquarters of Sanqing.

After Wei Kang announced the establishment of the "Wei's Science Award", he assigned specific tasks to his subordinates.

With the money, these administrative jobs are not difficult.

Moreover, he had been prepared for a long time before, and set up a science foundation under the Pangu Research Institute, but now he just took it out and operated it independently.

The only thing that is a bit difficult is the list of winners. He sent letters to experts and scholars he knew and did not know, asking them to nominate the list of candidates.

Wei Kang knew very well in his heart that the first competition was probably to attract others, and it didn't matter who the winner was, what was important was his attitude.

Only by taking the money out at a real price can everyone be convinced.

Only when scientists believe that they can really get money and form a routine can the Weiss Science Award take root in academia.

He also doesn't mind awarding the money to the losers of the past few Nobel Prizes, let alone foreigners, because the winners in biology and medicine will always be Chinese.

Once the foundation is laid down, what the next few sessions can do is to maintain fairness as much as possible. With him, this is not difficult to do.

Although he doesn't know much about mathematics and physics, as long as he chooses the research results that have the greatest impact on the world, he will not be awarded the wrong award.

No matter what kind of science and technology, it still has to fall into reality after all. No matter how sophisticated theories are, three, five, or ten years later, they will show a little power in the real world.

Science doesn’t end with publishing papers. Science is the knowledge of experiments, and it can’t fall into the theory of reality. It means it’s not that important, it’s just a castle in the air.

In this regard, whether it is his Weishi Science Award or the Nobel Prize, the standard he adheres to is the same.

Just when he was so busy, there was a knock on the door.

Tuk Tuk~

"Come in!"

"Hey, Li Zhong, why is your face so ugly, what's the matter?"

Wei Kang couldn't help being a little surprised when he saw Li Zhong who entered in response, his face sinking like water.

As a veteran of Sanqing, Li Zhong has no talent in scientific research, but he is serious and reliable in his work. After ten years of steady work, he also sat in the position of clinical project director of the group.

He is mainly responsible for drug clinical trials and marketing, as well as some generic drug business. He also serves as the deputy director of the cancer laboratory, and he can be regarded as a diligent butler.

Li Zhong smiled wryly, and said: "There is something that I must report to you, I hope it is my unfounded worries."

"Just say it." Wei Kang's face instantly became serious.

Li Zhong took out a paper material and handed it over: "I recently noticed a phenomenon in the case database, cancer patients over 60 years old, after taking our anticancer drugs for ten years, the recurrence rate is getting higher and higher gone."

"Although our anti-cancer drugs are also being iteratively upgraded, the personnel of the cancer laboratory have developed a drug delivery form of nano-pills, which makes the third-generation anti-cancer drugs more effective and less drug-resistant."

"However, the increasing recurrence rate of elderly patients is also a less optimistic trend."

"These patients over the age of 60 have a recurrence rate of nearly 20%, while patients over the age of 80 have a recurrence rate of more than 50%."

He looked dignified, with deep worry in his eyes.

"Mr. Wei, so many patients have cancer relapse after ten years. I'm afraid, I'm afraid it will cause a major blow to the company's anticancer drugs."

Wei Kang was also shocked when he heard this, he quickly took the report and read it carefully.

This is the latest report from a cancer laboratory, which analyzed the data of all cancer patients in the past 10 years, and finally came to an amazing conclusion.

For patients with serious diseases, Sanqing will follow up on the patient's condition, so it has accumulated a huge patient database.

Anticancer drugs have been available for more than ten years, and some patients who were cured of their cancer by taking medicine at the earliest stage gradually showed signs of recurrence.

Among them, most of them are elderly people over 60 years old.

As for those young and middle-aged people under the age of 60, the number of relapses is much less, only about 1%, and most of them have serious external stimuli, such as bad living habits, viral infections, and so on.

The good news is that these elderly people who have relapsed cancer basically got their disease under control after taking the medicine again.

The bad news is that after detailed testing, new cancer genes have been found in some elderly people.

For example, some patients got bowel cancer 10 years ago, but now they have lung cancer 10 years later.

10 years ago, it was colon cancer KRAS gene mutation, but now lung cancer pik3ca gene mutation has been detected.

This can only show that the probability of gene mutation in the patient's body is significantly increased, and the cancer gene is mutated again, which leads to the recurrence of cancer.

The report finally concluded that the cancers in these elderly people may not be caused by external factors, but by genetic mutations in the body. Taking anticancer drugs alone can only treat the symptoms but not the root cause.

This time, taking medicine to control the disease, it is likely that after two years, the cancer will change in another way, mutate a new gene, and make a comeback again.

Cancer in the elderly, like a chronic disease, lasts until the moment of death.

Wei Kang fell silent for a moment after reading the report.

The situation mentioned in the report is very grim. Although these relapsed patients took second-generation and third-generation anticancer drugs, the effect is still very good, and the deteriorated tumors disappeared quickly.

But those cancer genes are still in the patient's body. His medicine can only destroy the DNA of cancer cells, but not the cancer genes in the patient's body.

Anticancer drugs are like firefighters, they can only be used for emergency treatment, but cannot be cured at all.

Unless the genetic mutation can be eliminated, cancer is always like a maggot attached to the bone, and there is no way to completely eliminate it.

But eliminating genetic mutations is an impossible task.

All cells in the human body can only undergo a limited number of divisions, and after 30-70 divisions at most, the cells will die by themselves.

Cells have evolved such a mechanism to prevent cancer.

Each of its divisions is a DNA replication process, and errors often occur in this process.

It's as if when human beings copy an article, they often have one less character, one more character, or simply type a character into a homonym.

This is innocuous to an article and does not affect the expression of meaning at all.

But put it on genes, and it can have dire consequences.

When this gene abnormality accumulates to a certain extent, it will cause the cells to divide disorderly and become cancer cells.

Under normal circumstances, the human body has an error correction mechanism, which can often eliminate these crazy cells.

However, when the frequency of gene mutations reaches a certain level, more and more mutated genes accumulate.

When there are only a few lunatics, it is easy to eliminate them. When dozens or hundreds of lunatics pop up at every turn, any error correction mechanism will be exhausted.

Especially when fatal mutations have occurred in some key genes, things have become completely out of control.

Such as proto-oncogenes, which play an important role in the cell cycle and are essential for the normal division of cells.

Mutations in these genes, sometimes even just a single base change in the DNA, can cause them to malfunction, causing cells to divide uncontrollably. At this time, the proto-oncogene becomes an oncogene.

There are also some tumor suppressor genes, their function under normal circumstances is to inhibit cell canceration.

Among these genes, some can slow down the speed of cell division, some can repair DNA damage, and some can cause cell death at an appropriate time.

When mutations disrupt the function of these genes, cells divide out of control.

The normal operation of the human body, like a well-functioning country, depends on the various functions of genes.

And cancer is like anarchy, it makes the cells dirty, cruel and short-lived, so that the human body collapses.

They divide indefinitely, their growth has no direction and is not affected by external factors such as hormones;

They are involved in angiogenesis, where they trick the body into supplying blood;

They ignore any signal to stop growth, they resist apoptosis and avoid programmed cell death;

They metastasize and can spread to other parts of the body.

This process is entirely internal, a problem of the body itself.

Cancer is the human body trying its best to kill itself. It is suicide without permission.

It is the price humans pay for evolution.

If cells cannot mutate, humans will never get cancer, but humans cannot evolve and will always be the same.

In the real world, this means the extinction of species.

Although evolution is sometimes tough on individuals, overall it is good for species.

Thus, there is a gene mutation, and there is cancer.

In fact, it is an intrinsic property of the cell, not a disease.

It stems from an evolutionary need that also made humans.

Humans in the past didn't live long enough to develop cancer in large numbers.

With the advent of modern society, everything has changed.

Humans are living longer and longer, and as aging occurs, more and more gene mutations have released the demon of cancer.

Aging, on the other hand, is a phenomenon common to all species and begins within the organism.

It is possible to delay the process, but it is impossible to escape it forever.

Cancer is the fate of species evolution and the curse of eternal life.

If you want to avoid cancer, you can only solve the problem from the very source.

After thinking about this, Wei Kang couldn't help but smile wryly.

He muttered to himself, lost in thought.

"So the only way to eradicate cancer is to change human genes?"

"It's a pity that human genes are too complicated, and I'm afraid it can't be done now."

"However, there are genes that are prone to cancer, and there are also longevity genes that are not easy to become cancer."

"Family genes often play an important role in people who live longer."

"Living to 80 is basically the result of following a healthy lifestyle, but after that, it's almost entirely genetics."

"The probability of canceration is fundamentally a genetic problem."

"The best way to ensure a healthy and long life is to choose your parents and choose genes that are healthy and not prone to cancer."

"When it comes to the underlying design of life, I can't do anything about the century-old problem of immortality."

"I'm a scientist, not a god. I can't design a perfect human being. I can only sew, tinker, and be an all-round tinkerer." (End of this chapter)