I can extract side effects

Wei Kang recorded the prescription on the system panel, but he did not synthesize the medicine according to the above method.

Instead, he copied a copy of the compound molecule, then walked out of the office, and summoned the three generals again.

The company cannot always rely on him to develop drugs, since a research and development team has been established.

They must be allowed to function as they should.

For this new small molecular compound, he didn't want to use the synthetic method provided by the system, but asked the three of them to find a new synthetic route together.

Even if their synthetic methods cannot perfectly achieve their goals, they can gain a deeper understanding and understanding of drug development in the process of studying synthetic pathways.

It is equivalent to based on the known results, the three of them work together to reverse, so as to find one or more correct synthetic routes.

In this process, the understanding of drug molecules will be greatly deepened, and it will be easier to improve the drug in the future.

He always felt that in the various prescriptions given to him by the system, the most important thing was not the synthesis method inside, but the final drug molecule.

These drug molecules perfectly realize the treatment without side effects, and must have a very mature and perfect structure. If we can do further analysis, thoroughly understand the rules behind this, and find more synthetic routes, it will definitely promote the in-depth understanding of basic chemistry. Research.

It is not enough to know why, but also to know why.

The basic principles and underlying rules are the greatest value of these drug molecules.

Although he doesn't have enough drugs, as long as he continues to extract them through the system, there will definitely be enough drug molecule libraries for chemists to figure out why.

There are so many smart people in China. If these three people are not enough, then he will continue to recruit chemists, biologists, and even mathematicians. Hundreds, thousands, ten thousand people, no matter how many people, must make this drug molecular analysis project do it.

If it is really possible to analyze any chemical principle from it, even the slightest, it will be a progress in the history of human science and technology, and it is also the greatest value of this system.

Soon, he showed the drug molecule of gamma secretase inhibitor on the computer in the laboratory.

While admiring the flawless structure and feeling good about himself, he couldn't help asking for opinions.

"I looked at some of the drug molecules that your group had constructed before, and suddenly I had this idea."

"How? What do you think?"

The laboratory fell into a strange silence, and no one made a sound for a long time.

He looked back, and saw the three people behind him all gaping, their eyes wide open, staring at the screen, their faces were flushed, their breaths were short of breath, and their expressions were mesmerized.

He couldn't help being startled, clapped his hands vigorously, and shouted loudly: "Don't bother watching, just tell me what you think."

Clap clap!

The crisp applause sounded, and the three of them were awakened immediately.

The three of them came back to their senses as if they had just woken up from a dream, and looked at each other a few times, eyes full of surprise.

Chen Yiqing opened his mouth, as if he wanted to say something, but no sound came out. He tugged at the collar of his shirt, unbuttoned it, took a deep breath, stretched out his right hand unconsciously, and touched his face. Only to find that his forehead was covered with sweat.

Wen Renlong suddenly applauded vigorously: "It's a good thing, the boss, this drug molecule looks so similar to the structure of anticancer drugs, it must have been improved based on the same principle. This is a fantastic idea. , we really can’t catch up with the horse.”

He clicked his tongue in admiration, his face intoxicated, as if a pervert was looking at a painting of beautiful women.

Tang Que was the only one who could keep calm. He kept nodding and waved his hands unconsciously in front of his chest, as if he was secretly deducing something in his mind.

Chen Yiqing took out a tissue, wiped the sweat off his face, and asked with difficulty: "Mr. Wei, this is, is this really the molecular structure of a γ-secretase inhibitor?"

Wei Kang nodded affirmatively and said: "That's right, I think it will definitely work. Your first task is to study its synthesis pathway, synthesize this new drug in the laboratory, and then carry out follow-up tests. Is there any problem?" ?”

Wen Renlong looked excited and waved his fists: "No problem, this is the moment I dreamed of. Discovering a molecule and developing it to save tens of millions of lives is such a great feeling. I have completely fallen in love with it." this place."

Chen Yiqing recovered from the shock, and was already thinking about the next steps: "Yes, since Alzheimer's disease is a brain disease, our follow-up administration method must consider the problem of breaking through the blood-brain barrier. At the same time, safety and toxicity The physical test should also be more perfect, and the possible impact of some common diseases of the elderly should also be considered.”

Tang Que crossed his hands in front of his chest, and suddenly asked, "Mr. Wei, what about the second mission?"

Wei Kang glanced at him approvingly, and then said: "The second task, I will open the authority to you, you have to study all the prescriptions developed by Sanqing, especially these drug molecules, I just discovered it by chance. Cancer drugs, I don't know the principle behind them."

"So from a scientific point of view, you need to study the principles in depth together, and it is best to summarize something. This will also help us develop drugs in the future."

Tang Que's eyes lit up, and he exclaimed, "My God, this idea is amazing, very attractive, let's start, I can't wait."

Seeing the eagerness of the three of them, Wei Kang smiled with satisfaction.

Generally speaking, traditional drug design lacks a mature and perfect discovery path, and has great blindness. Generally, more than 10,000 compounds need to be screened to obtain a new drug. Therefore, the development efficiency is very low, and it is difficult to quickly obtain suitable new drugs. Treat more and more intractable diseases.

With the development of computer technology and computational chemistry, molecular biology and medicinal chemistry, drug design has entered a rational stage.

Computer-aided drug design (CADD) is the basis of drug molecular design. It has developed into a complete and emerging research field, which greatly improves the efficiency of drug development and provides people with new ideas and hope for success in overcoming some stubborn diseases. .

It is based on the research results of life sciences such as biochemistry, enzymology, molecular biology and genetics, and aims at the potential drug design targets revealed in these basic studies, including enzymes, receptors, ion channels and nucleic acids, and refers to Design rational drug molecules based on the chemical structure characteristics of other analogous ligands or natural products.

In time, drug design will enter a new development period, and the ancient dream of human beings - the era of theoretically designing the required substances and then synthesizing them is becoming a reality!

In the pharmaceutical synthesis process, the retrosynthetic analysis method is the most basic and commonly used method for the design of organic synthesis routes.

The prominent feature of retrosynthetic analysis is reverse logical thinking, the thinking process of deriving simple starting materials from complex target molecules, which is just opposite to the actual process of chemical synthesis, so it is called "reverse" synthesis, or "reverse" synthesis.

The contemporary master of organic synthetic chemistry, Professor E. J. Corey of Harvard University formally proposed the retrosynthetic analysis method in the 1960s. And this is Chen Yiqing's mentor when he was a PhD student at Harvard.

The process of retrosynthetic analysis can be simply summarized as follows: based on the structural analysis of the target molecule, the three steps of cutting, determining the synthon, and finding synthetic equivalents are repeated until a suitable starting material is found.

The more comprehensive the knowledge of chemical reactions, the more open the design of synthetic routes.

When designing a drug synthesis process route, it is usually hoped that the route should be as simple as possible to complete the construction of drug molecules with the fewest reaction steps. But this cannot be at the cost of sacrificing the quality of the drug, the purity of the drug must be ensured.

This requires the designer to fully understand the selectivity of the reaction, try to use a high-selectivity reaction, reduce the formation of by-products, and obtain high-quality products.

Fortunately, these three doctors all have rich experience and comprehensive and profound knowledge. With ready-made drug molecules, it is not too difficult to reversely deduce the synthesis method.

A month later, the new drug was finally synthesized in the laboratory.