I Have A Super USB Drive

19 - Rebuild the immune system

"Rebuild the immune system?" Wang Wei looked confused.

"Do you know what is the most effective clinical treatment for leukemia?" Chen Chen asked rhetorically.

"Uh, I haven't paid much attention to it. This should be biomedical knowledge." Wang Wei scratched his head.

"Simply put, leukemia is a kind of disease of hematopoietic stem cell lesions. The hematopoietic stem cells of the human body undergo malignant proliferation for some reason, thus inhibiting the normal hematopoietic function of the human body. The principle is similar to that of cancer, so it is also called 'Blood cancer'."

Chen Chen explained, "The most effective way to treat leukemia in the medical world today is to perform bone marrow pairing, select a volunteer with the closest genetic similarity to the patient, and then the patient will receive chemotherapy and radiotherapy to kill the hematopoietic stem cells in the bone marrow. "

"The volunteers are then injected with a drug called a 'mobilizer', which stimulates the massive growth of blood-forming stem cells in the bone marrow and releases them into the blood, where the hospital collects these stem cells and injects them into the patient."

"Because the patient's hematopoietic stem cells have been previously killed, a niche is left in the patient's body, and the newly injected hematopoietic stem cells have an effect called 'homing' and spontaneously enter the patient's bone marrow, within one to two Rebuild the patient's immune system over a period of months."

Chen Chen concluded: "And this is called bone marrow transplantation. The healthy hematopoietic stem cells of the volunteers are used to replace the diseased stem cells of the patient. In fact, the so-called bone marrow is not the real bone marrow, but only the hematopoietic stem cell transplantation."

"What does that have to do with your experiment?" Xia Yin asked impatiently.

"My third experiment is to take a group of aging rats, clone them, and then extract young hematopoietic stem cells and mesenchymal stem cells from the clones."

"Then, as in the treatment of leukemia, the hematopoietic stem cells and mesenchymal stem cells from the rats were killed and replaced with cloned stem cells."

Chen Chen pondered, "If it succeeds, will this rat, which was originally dying, be restored to its youth?"

"Yes, it shouldn't be possible, right?" Xia Yin showed a shocked expression.

"Why not?"

The corner of Chen Chen's mouth twitched, "Mesenchymal stem cells have the ability to differentiate into muscle cells, liver cells, osteoblasts, fat cells, chondrocytes, stromal cells and other cells."

"Why does the human body age? It's because of the functional decline of human muscles, bones, and internal organs, but why do human muscles, bones, and internal organs age functionally? That's stem cell aging."

"Young people's stem cells can continue to replicate to replace aging muscle cells, bone cells and visceral cells, so young people's metabolism is much faster than adults, but when humans reach the age of 30, stem cells will age and replicate. The speed of replacement gradually cannot keep up with the aging speed of the cells themselves, so the human body will also show signs of aging..."

Chen Chen said, "So, if the human body's mesenchymal stem cells and hematopoietic stem cells can return to youth, can the human body also return to youth? Even if other internal organs cannot be rejuvenated, the muscles, bones, hematopoietic functions, etc. Rejuvenation of some body functions is something that many people can't achieve, right?"

Hearing this sentence, Xia Yin immediately showed a thoughtful look. After all, she is already a senior, and her knowledge is wider than Wang Wei's. She also understands better than Wang Wei that if this experiment is successful, it will affect modern times. What a shock to the medical world.

"If it is really successful, this kind of result is enough to vote in the first district." Xia Yin showed a look of longing.

"I have contacted Mengan Pharmaceutical Company, and I can use their channels to help us purchase experimental drugs. I asked about the price, which is absolutely fair and just."

Chen Chen added, "We can start the experiment today.

"

"Then let's go now." Xia Yin agreed, "Start the experiment early, maybe you can really complete the experiment within three months!"

The three set off immediately and took a car to the building of Meng'an Pharmaceutical Company. The Mediterranean man who had brought Chen Chen and Xia Yin to visit also waited for a long time.

It's only been a few days that the Mediterranean Sea above the Mediterranean man's head seems to be wider.

"You are finally here. If you don't come again, the leaders will scold me to death."

The Mediterranean man smiled bitterly, "I shouldn't have agreed to the conditions for starting the calculation of the rental time after the winter vacation, which cost us more than a week in vain."

"Have you bought everything?"

"I bought it. I have bought the head-mounted experimental recorder and various experimental medicines. I have already helped you move to the fifth floor."

The Mediterranean man took out three magnetic cards and handed them to Chen Chen, "This is the laboratory access card. From now on, we will send someone to the laboratory for inspection once a month. If there is any damage, please compensate according to the price. I hope you will take good care of our laboratory equipment and not pollute it. lab environment."

"Of course." Chen Chen took the magnetic card.

"And this." The other party took out a business card again, "This is the source contact of our laboratory. If you are short of experimental drugs and experimental animals, you can call this phone to buy."

Chen Chen took the business card, which showed people from the Shangdu Animal Experiment Research Center, and handed the business card to Xia Yin.

Because all the agreements had been signed before, after sending Chen Chen and the three to the fifth floor, the Mediterranean man said goodbye and left.

"The whole floor is a laboratory you rented?"

As soon as Wang Wei reached the fifth floor, he wandered around, touching this and that with a novel look on his face, "This is too extravagant, it is better than the laboratory environment of the school, by the way, where does the GMP laboratory come from, why didn't I See the entrance?"

"It's in the basic laboratory."

Chen Chen put on disposable slippers and walked into the basic laboratory, "The blue alloy door in front is the entrance, and there are just two compartments in the back of the basic laboratory. I asked them to buy three beds and put them in it. Used as a lounge."

The two followed, and sure enough, they saw a lot of items piled up in the basic laboratory, including three folding beds.

In addition, there are various encapsulated chemicals, these medicines want to be transported into the clean area, I am afraid that the three of them will be busy for a while.

As students of the School of Biological Sciences, it is not the first time for the three of them to enter the sterile laboratory. The relevant procedures are still known. Wang Wei is responsible for transporting the drugs into the buffer corridor, Xia Yin is responsible for placing them in the transfer window, and Chen Chen is responsible for carrying the medicines into the buffer corridor. Responsible for correspondence in the GMP laboratory.

As the three of them get busy, they can divide their work for a while, and do their own things in an orderly manner.

But before waiting for a while, the elevator door opened again, and a person walked in with a small cart of sterile boxes.

"Is this what you call an SPF laboratory animal?"

"Yes." Wang Wei was in charge of delivering medicines to the outside world, and immediately notified Xia Yin to come out to check the experimental animals and sign.

These experimental animals were 60 SD rats and 10 experimental rabbits. After a simple handover, the two settled these animals into the animal breeding room.

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