I Have A Super USB Drive

"Nature" magazine published several papers on rapamycin in 2009.

Some scientists divided nearly 2,000 20-month-old mice, equivalent to 60-year-old humans, into two groups, one group was mixed with rapamycin in their food, and the other group did not.

The final experimental results were unexpected. The lifespan of rats ingested rapamycin increased by 14% on average compared with the other group.

In the last century, scientists discovered two ways to extend the life of mammals, one is to "repair" genes, and the other is to reduce fat intake by controlling diet.

Of course, there is no need to say more about the method of repairing genes, that is what Medpod 3000 can do.

The purpose of reducing fat intake is to reduce the activation of a protein molecule called TOR.

TOR is a signal molecule secreted by the human body, which can regulate the growth of each cell of eukaryotes. When TOR is activated, it will cause cells to synthesize biomolecules, increase cell mass, increase cell size, and synthesize proteins and nucleic acids. increase, and promote cell enlargement and weight.

If you compare a human being to a large precision machine, even if the energy source continuously absorbs energy from the outside world, the various "parts" in the body will wear out with the years of use, and the activation of TOR is like meeting the basic needs of life. Add extra work to the parts to make the machine age faster.

The reason why rapamycin prolongs the lifespan of mice is likely because it "tricks" the mice's bodies into believing that their fat intake has decreased.

Of course, all of this is not supported by any human clinical trial data, and all applications for clinical trials related to the use of rapamycin to prolong life have been officially rejected.

Even so, in the period from 2010 to 2020, many doctors can still hear gossip about taking rapamycin secretly.

However, after ten years, rapamycin, a "life-prolonging drug", has overturned again.

"Journal of Clinical Medicine" published a paper in April 2020, saying that too low TOR activity will trigger the aging of the hematopoietic system.

In short, at the cellular level, inhibiting TOR can deceive the body and delay aging, but in the hematopoietic system, TOR activity is needed to support itself.

Excessive inhibition of TOR will directly cause the aging of cell niches in the bone marrow, and then lead to the aging of hematopoietic stem cells, which can be described as success or failure.

In fact, Chen Chen also considered improving rapamycin back then.

Or counteract the side effects by using drugs in combination, and find out a special drug that prolongs life.

It was only later that Chen Chen discovered that in the field of stem cells, the effect on the human body was far greater and more potential than this drug, so he gave up rapamycin, turned to specialize in stem cells, and finally researched the aging reversal treatment items.

Now, in the face of immunosuppression, Chen Chen once again thought of this legendary drug, which can be regarded as a kind of retrospect.

For the next half month, Chen Chen picked out a clone, and gave it a combination of rapamycin, cyclosporine A, and FK506 every day. The combination of the three drugs quickly wiped out the clone's immune system. suppressed.

After the clone's immune system was suppressed, Little X extracted the clone and put it on the stretcher again.

And this time, the clone was no longer injected with T-002, but with another improved T-003 after two or two failures.

Compared with T-002, the T-003 virus is more complete, knocking out two RNA errors, and it is more compatible with Chen Chen's genes.

Sure enough, in the face of T-003, although this clone has suppressed the immune system, it easily broke the record of the previous clone of 3 hours and 28 minutes, and did not die for a full six hours after the virus was injected.

Not only that, because the DNA in the clone body is undergoing earth-shaking changes, Xiao X constantly injects a large amount of nutrients such as glucose and carbohydrates into the clone body, in case the clone body does not die from the T virus, but from nutrition. bad above.

In Chen Chen's eyes, the clone continued to swell almost at the speed of a steamed bun, and soon grew to a height of two meters. The muscles all over its body were tangled, like a smaller tyrant.

This was the first time Chen Chen and Xiao X had seen such a situation.

However, the clone died in the end, and his body still couldn't survive the transformation of the T virus, but it was worth congratulating that the clone lasted a total of eight hours.

The extension of time gave Chen Chen new hope.

Looking at the clone that finally turned into a zombie, Chen Chen looked thoughtful, "Although it still failed, this experiment is of great reference."

"Yes, there is no problem with our direction."

While controlling the black knight to collect the DNA of the clone, Little X said, "Rapamycin can effectively inhibit the body's rejection of the T virus. Generally speaking, the act of suppressing immunity is indeed death. After all, the immunity of ordinary people There is no way to fight against the T virus, and suppressing immunity will only make people die faster."

"However, if this T-virus matches the host's DNA, it will be a completely different result."

As he said that, Xiao X compared the DNA of Chen Chen's tyrant clone with the DNA of the latest clone that turned into a zombie, "Look, we are getting closer and closer to the correct answer, but we only have A mature clone is now, and it will take another six months for a new batch of clones to mature."

As he said that, Little X became distressed, "And the closer the improved T virus is to that formula, the slower the progress will be."

"It's normal."

Chen Chen nodded, "It's like a game. Modifying a BUG will inevitably lead to a new BUG. Although the code can be continuously corrected to make the game close to perfection, as the game becomes more and more perfect, it is difficult to modify the BUG. It will inevitably increase, these are all affecting the whole body..."

"So, in the end, it's all about luck?"

Little X asked.

Chen Chen nodded and sighed, "It seems that the original ancestor virus was improved into a perfect T virus, and there was an element of luck in it, and the original intention of research on many special medicines in the world was not for this disease, they The appearance itself is a kind of luck."

"It can even be said...scientific research itself has a certain element of luck, which is unavoidable, but the diligence and ability of the researchers can make up for this luck."

"After all, luck will not always be on our side, but hard work and ability can..."

After thinking about it, Chen Chen added again, "Of course, money is also acceptable."

Little X: "..."

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