Into Unscientific

  Chapter 52 begins to synthesize!

   "Old Qiu, what's the matter?"

  As soon as Xu Yun returned to the laboratory, he asked Qiu Sheng who was holding a test tube:

   "It's only been more than an hour, right? The substitution reaction is completed so quickly?"

   "That's right, wait for me to put this thing away first."

  Qiu Sheng carefully put down the test tube upon hearing this, walked to another table, picked up a paper report, and handed it to Xu Yun:

   "To be precise, it is one hour and twenty-seven minutes. The activity of 5-epoxy-1-hexadecyne seems to be much higher than we expected."

  Xu Yun took the report and glanced at it, then nodded:

   "This kind of curve. It seems that it should be a problem with the temperature setting. It is probably related to the fact that I just asked Xiao Zhao to raise the temperature.

  Old Qiu, I am not a major in chemistry. Is the activity of 5-epoxy-1-hexadecyne so much different at 180 degrees and 170 degrees? "

  Qiu Sheng pondered for a while, then shook his head:

  “I know about 5-epoxy-1-dodecyne, but hexadecyne seems to have a relatively limited understanding of it in China.

  The two temperature environments of 180 and 170 are quite common, but it is difficult to add a substitution reaction. After all, carbyne is a thing. There are more researches on materials science now. "

  Xu Yun nodded thoughtfully, and stopped talking.

  Carnyne refers to a chain of carbon atoms joined together by double bonds or alternating single and triple bonds.

  Carbyne has been proven to be more than 200 times stronger than steel and twice the tensile strength of graphene. It is considered to be the strongest material in the world, 40 times stronger than diamond.

   It was proposed in 1885, but it was not until April 21, 2016 that the University of Vienna came up with a carbon chain composed of 6400 carbon atoms.

  From the perspective of mass production, it is indeed a new product.

  Epoxycarbyne is more complicated, and Xu Yun actually didn't expect it to be the final product.

  The purpose of introducing this substance is mainly to allow epoxy terminal alkyne to react with 1-bromo-2-pentyne to form epoxydiyne under the catalysis of cuprous iodide.

  Finally, the target pheromone (3Z, 6Z, 9S, 10R)-9,10-epoxy-3,6-eicosadiene is obtained by catalytic hydrogenation with nickel acetate/sodium borohydride.

  Therefore, 5-epoxy-1-hexadecyne is an intermediate product in the whole reaction. Xu Yun's original idea was just to hope that it can stabilize and play a role of connecting up and down.

  But judging from the current situation

   This thing seems to have some lively chemical properties under certain circumstances?

  Xu Yun silently kept this situation in mind, and planned to take the time to ask more professional bosses, and at the same time said to Qiu Sheng:

   "Okay, let's move on."

  Qiu Sheng nodded, followed Xu Yun back to his position, and started to operate again.

  Perhaps it was because they had eaten at noon. Compared with the relatively dry run-in in the morning, everyone in the research group in the afternoon seemed to have added lubricant, and they came in and out very smoothly.

  After working overtime all night, the research team finally synthesized the target pheromone in the early morning of the next day, nearly ten hours earlier than Xu Yun had expected.

   Nothing to say all night.

  At 1:30 p.m. the next day, Xu Yun stood in front of the main console again.

   "Dear brothers and sisters."

  He looked around, the last time he remembered seeing such a gathering of six people seemed to be yesterday:

   "Through everyone's unremitting efforts yesterday, we have passed the first step of this project. Let's not talk nonsense, let's go tonight with extra meals!"

   "Papa Papa—"

   As soon as the voice fell, Tang Yiqiu and others applauded.

   Then Xu Yun paused and continued:

   "In addition, starting today, we will carry out the synthesis of pheromones and imidacloprid. There are two main steps in this link:

   One is the cyclization of a given CH3 through asymmetry, and the other is the synthesis of new substances.

  The structure of the target pheromone we synthesized is very complex, and no one can be sure whether a CH3 can be accurately removed for cyclization, so please work together to achieve a good result!

  Okay, that’s all for now, let’s start experimenting! "

   As he spoke, he waved his hand, and everyone returned to their seats one by one.

  Xu Yun came to the main console and performed the main steps himself.

   "Little Tang."

  Xu Yun was seriously preparing for the early stage, and said to Tang Yiqiu:

   "Add protective argon gas first!"

"clear!"

   After the argon gas was added, Xu Yun began to add 50 mol of anhydrous LTHF and 20 grams of hexamethylphosphoramide into the 250mL Schlenk reaction flask, and stirred to dissolve.

  After the treatment, he lowered the temperature of the reaction system to -78°C, added 2.52g of propargyl alcohol, then added n-butyllithium dropwise with a syringe, and raised the temperature to -30°C.

   After another three hours, the stirring reaction was sufficient to occur.

   "Little Tang, prepare 22.50 mmol of 1-bromoundecane!"

at the same time.

  In the invisible microcosmic realm, some wonderful reactions are happening quietly.

  LTHF, strictly speaking, it should be called LT-HF.

  The former means low temperature, that is, low temperature, and HF means hydrogen fluoride.

  LTHF and hexamethylphosphamide are like two young boys and girls who are in love. They like each other but dare not express it.

   At this time, the invisible 1-bromoundecane appeared.

  It is like a common punk in novels, blocking the weak HMP in one afternoon.

   "Don't come here, let go!"

   "Hey, little sister, do you want to get on Dua Lang?"

  1-Bromoundecane approached the hexamethylphosphoramide, pushing her close to the corner, and even grabbed her little hand.

   "Stop it!"

At this moment, LTHF, a pure love boy without tauren attributes, appeared. He first picked up a stone from the floor (one hydrogen was decomposed from propargyl alcohol), and threw it vigorously at 1-bromoundecane .

  The stone hit 1-bromoundecane heavily, splashing a red blood stain (three carbons).

   While 1-bromoundecane was clutching his head and howling, LTHF pulled up hexamethylphosphoramide, turned around and ran away.

   After running to an uninhabited alley, HMP raised his head, and HMP looked at LTHF with teary eyes:

   "Why did you save me?"

  LTHF scratched the back of his head with a smile, his eyes wandering:

   "because. because"

   After mumbling for a long time, he still didn't have the courage to say the phrase "I like you" in his mouth.

   Just when the young man hesitated to speak, the corner of his mouth suddenly felt soft and wet.

   His eyes widened for a moment, and he stared straight ahead in a daze, but suddenly met six pairs of eyes full of love.

  Hexamethylphosphoramide stretched out three hands representing nitrogen, tightly embraced LTHF, and said with a second mouth representing oxygen:

   "LTHF, I like you."

"Snapped!"

   At the same time, in the laboratory, Xu Yun clapped his hands heavily:

   "Perfect, the reaction is done!"

   It’s time to crowdfund snacks with everyone again. Do you have any delicious snacks to share? Prepare for a wave of inventory

  (end of this chapter)