Rebirth of the God-level Xueba

Chapter 60 Studying Coenzymes

The reason why Yang Rui's laboratory is affiliated with and purchases equipment through the West Fort Meat Factory is because there is a biochemical pharmaceutical team under the West Fort Meat Factory.

Some people may wonder how there can be a pharmaceutical workshop in the meat joint factory, but in fact, until the 1990s in China, most of the biochemical pharmaceutical factories were located in the meat joint factory.

This is determined by the nature of the biochemical pharmaceutical factory. Primary biochemical pharmaceuticals are produced from animal organs. If you want fresh animal offal, but you don’t have good storage and transportation methods, don’t set up the factory in a meat factory. , and where can it be set?

At that time, the biochemical pharmaceutical factory was not called a biochemical pharmaceutical factory. It was generally called an organ biochemical factory, or an organ biochemical workshop. In terms of units, it is already a top-ranked large factory in China.

Journals and books related to biopharmaceuticals are now called "Organ Biochemical Pharmacy" or "Animal Biochemical Pharmacy". The commonly used microbial fermentation method and plant cell culture method are still under research, not to mention the chemical synthesis method, which will always be the most difficult and the last method to be popularized.

There are many organs that can be used for pharmaceuticals. The pancreas can extract insulin and pancreatic enzymes, the heart can extract coenzymes, and the brain can extract cholesterol... In 1982, all biological products were expensive and sold well. of.

However, the biochemical and pharmaceutical teams of the West Fort Meat Factory are not taken seriously. Their most profitable project is the export of white striped meat to Europe, earning millions of dollars in foreign exchange every year, which is also the proud capital of the factory leaders.

In contrast, although organ pharmaceutical products are valuable, the cost is also staggering. Using the method in the 1980s, a kilogram of organ may only extract a few tens of milligrams of the product, and other solvents and materials are consumed during the process. The gain outweighs the gain . Moreover, the biochemical and pharmaceutical teams of the West Fort Meat Factory cannot produce relatively common biochemical products in the 21st century. In terms of their technology, what others can do is not cheap, and what others cannot do is even more incompetent.

Of course, Yang Rui did not have such a problem.

After 30 years of development, he used the laboratory methods of later generations, and his output was higher than that of the biochemical team of Xibao Meat Joint Factory. Of course, the size of the biochemical team at the Xibao Meat Joint Factory is actually the size of the laboratory, just with a few more people.

Yang Rui is not going to directly sell biochemical products to make money. These things are still under the monopoly of the state. It is troublesome and tiring for individuals to make a lot of money. Continuous production means that well-trained workers are prone to mistakes, let alone him and a group of students.

It is probably feasible to get honor, but it is Yang Rui who cares the least.

Instead of making less money for honor,

Yang Rui is more willing to pave the way for some papers.

When he was a graduate student, he spent most of his time looking for papers for his teacher. Usually, when a tutor makes a list, he has to check the information for a week. It is impossible to say that the periodicals and books he has read are integrated, but he has to scan them all the time.

As a result, the papers are now in his head.

Yang Rui only needs to choose some simple ones to redo the experiment, and then rewrite it.

As for how simple it is to make his small laboratory work, Yang Rui's judgment method is the price of the experimental equipment.

The simpler the equipment, the better, the less equipment used, the better, the simpler the experiment, the better, and the easier it is to buy raw materials.

After screening in this way, Yang Rui selected the research on Coenzyme Q10.

Enzymes are catalysts for the work of organisms, and coenzymes are the so-called "second substrates" that assist enzymes in their work. Common coenzymes include vitamin b1, vitamin b2, folic acid and so on. These coenzymes, which are very cheap in later generations, are all produced by chemical synthesis, and the cost of a bottle can be reduced to a few cents, but in the beginning, they were still obtained by extraction. For example, folic acid, which all pregnant women should eat, was first isolated from spinach leaves, and hence its name.

From this point of view, the so-called dietary therapy in China is somewhat meaningful.

Coenzyme q10 is a coenzyme discovered late, which was first extracted from animal heart tissue. Its research history is very long.

As early as 1974, Japan's Eisai Pharmaceutical Company sold it as a heart disease drug, which attracted the attention of many biologists. Therefore, in the next few years, three international symposiums were held in one go to conduct extensive research on its biomedical and clinical applications. China also produced coenzyme q10 in 1976.

And until Yang Rui crossed over, coenzyme q10 was still a research hotspot, biologists were still studying its biomedical and clinical applications, and pharmaceutical companies were still studying its production methods. Although each research had made great progress, coenzyme q10 was still Not a cheap biochemical.

In 1982, coenzyme q10 was naturally more valuable, whether it was a product or a research paper.

It is precisely because 30 years later, coenzyme Q10 is still a research hotspot, and Yang Rui has been able to read many related papers. As long as the experimental equipment is in place, he can copy a lot of articles.

In fact, there are experts and professors at home and abroad who have spent their whole lives researching coenzyme q10 all over the place. Cutting off their ears can almost fill a basket.

Adhering to the idea of ​​low-key accumulation, Yang Rui first purchased beakers, flasks, triangular flasks and other instruments, ethanol, propanol and butanol and other reagents in the name of the school, and then in the name of the biochemical pharmaceutical team of Xibao Meat Joint Factory, he sent to Pingjiang Biochemical Pharmaceutical Factory Directly ordered two batches of refined coenzyme q10.

He was going to write an article on how to measure coenzyme q10 more accurately. Compared with the direct production of coenzyme q10, this kind of article was not weaker, but simpler.

While waiting for the items to arrive, Yang Rui began to teach biology to the members of the Ruixue group, and at the same time selected his own experimental assistants.

Li Tieqiang and others will continue to come to the classroom to attend lectures, but they can no longer get test papers for free, and Yang Rui will not correct their test papers, let alone make targeted curriculum tilts.

For students who have not enjoyed this kind of treatment, it may be difficult for them to understand the role of the so-called tilt, but for Li Tieqiang and others who have enjoyed special treatment, they immediately felt the change.

The improvement of grades has become more difficult.

They couldn't tell the reason, but they panicked even more.

Someone found Yang Rui at night, hoping to rejoin the Rui Xue Group, but Cao Baoming, who was in the same room, blocked him without hesitation.

Li Tieqiang and Wang Wanbin also tried to strike up a conversation in the cafeteria, but they were still rejected without hesitation.

At the same time, the curriculum of the Ruixue group has gradually progressed from reviewing junior high school, re-studying high school, and progressing to real high school review.

More difficult questions and more complicated review routes further widened the distance between the Ruixue group and other students.

At this time, Li Tieqiang and others regretted it even more, but it was in vain.

Yang Rui had so many cards in his hand that he didn't have to say anything to block them out completely.

And the more bland the treatment, the more irritating it is.

Li Tieqiang and Wang Wanbin simply recruited more than a dozen people, organized a study group of their own, and then studied hard, encouraged each other, and tried to surpass the Ruixue group.

However, they are all old students who have worked hard to repeat for two or three years. If the old method is useful, why do they repeat it year after year.

What's more, the members of the Ruixue group study diligently in a more scientific curriculum schedule, and the gap between the two sides will only widen, but will not narrow.

A week later, when the first batch of simple instruments ordered by Yang Rui arrived, there were only two or three people left in the newly formed study group, which existed in name only.

More people set their sights on this laboratory.

In the history of West Fort Middle School, there has never been such a configuration as a laboratory.

Even Principal Zhao couldn't help coming to this small house by the garden, observing and touching those crude flasks, burettes, pH test papers and other things one by one, and sighed: "You should have gone to school two years earlier, Old Tan Might be able to stay."

Lao Tan is a chemistry teacher at a university. Because of a crime, he ran to Xi County, and was later protected by Principal Zhao. However, when Yang Rui was in high school, Old Tan rehabilitated and returned to the city.

Yang Rui didn't take Principal Zhao's emotion seriously, and said with a smile: "The current configuration of this laboratory is not as good as that of a middle school in the provincial capital, and even if it is fully equipped, it is not as good as a laboratory of Hedong University. Teacher Tan can't do experiments if he stays. , can only be wasted forever."

"Why is teaching a waste of time?" Principal Zhao knew he was right, but still refused to admit it. He shook his head and said, "I think your laboratory is good enough. You can get what you want. The ones in bottles and cans are better than those in No. 1 Middle School." There are many complete ones, what experiment can’t be done?”

Yang Rui smiled, and said: "The laboratory of No. 1 Middle School is for teaching. How can I compete with them? Moreover, in terms of assets, this laboratory is currently only worth 1,000 yuan. How can the laboratory of No. 1 Middle School cost tens of thousands?" .”

"Fart. They accepted a batch of experimental instruments in 1978. Otherwise, they would be poor and useless now." Principal Zhao turned his face away, rubbed his hands and said, "Otherwise, let the students of our school come to you too. Do experiments in this laboratory?"

Yang Rui spread his hands, and said, "Experiments require materials. If you are willing to pay for reagents, I can substitute for free."

Principal Zhao was stunned for a moment and asked, "How much is the material?"

"It's a few cents per person, depending on what kind of experiment you are doing, and an average of 20 cents is what you need." In the 1980s, prices were cheap, and experimental consumables were not cheap.

Principal Zhao quickly calculated in his mind that there are more than 400 people in the school, and they will get at least 100 yuan for the experiment once a month. One semester is four months, and the cost of doing it is 400 to 500 yuan.

After getting this result, Principal Zhao immediately changed his words: "It's too troublesome to do the experiment. It's just such a big room... let the students visit it for free."

Yang Rui wanted to say, can free visits make the room bigger?

However, looking at the curious faces of the students around him, Yang Rui couldn't help but soften his heart, and said: "Just visit it. However, if it's just a free visit, I won't deliberately arrange the content of the experiment. It's up to me to explain or not. You have to listen to me."

"no problem."

"You don't need to visit by class anymore. Let interested students sign up, and I will inform them of the time. This will probably reduce the pressure of visiting."

"no problem."

"Students who come to visit should help me clean the laboratory and clean the experimental equipment."

"no problem."

"That's how it is. If there are students who are really interested, I will find an opportunity to arrange for them to do experiments in person." Yang Rui didn't wait for Principal Zhao to speak, and then said: "The number should not be too many. The school has no funds, and neither do I. "

If you really want to learn something by doing experiments, the minimum is to do it once every half a month. After a semester, it costs 1,000 yuan, and after a year, it costs 2,000 yuan. Yang Rui can't afford it.

Principal Zhao nodded without hesitation, and then made his own request: "In the future, if someone comes to visit, you have to say that the laboratory belongs to the school."

"Whatever, anyway, the instrument is under my name." Yang Rui still has the invoice in his hand.

Principal Zhao ignored Yang Rui's Xiao Jiujiu, stroked his beard and said, "Shengli Middle School built a cinder road last year. Dong Gouzi invited me to visit it twice. I have to recruit this place back."

"If someone comes to visit, you have to notify in advance, otherwise don't blame me for closing the door and padlocking." Yang Rui made a small threat. He actually doesn't care about people coming to visit. Writing a thesis is to gain fame, and displaying the laboratory is also to gain fame. You are reading, if any!

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