Sleepless Doctor

　　"In the beginning, his method was to extract streptococcal abscess, which is benign pus, and then culture it with pure cells.

　　 The last bacterial liquid that came out was Dr. Colley’s original “cancer vaccine”. "

　　 "Awesome!" Yun Lan was surprised.

　　 Cancer vaccine, these four words alone sound particularly powerful.

　　 "Hehe." Wu Mian smiled, "When I saw this place back then, I started to search for information and realized that Dr. Colley was not in love with the girl Dahir."

"why?"

"Because John Rockefeller Jr. sponsored Dr. Coley's research. I wonder why Rockefeller's heirs would be interested in cancer vaccines. So I found some information and found out that Dasher was Jr. John's goddess. "

　　 "..." Yun Lan was blank, "Does this have anything to do with immunotherapy?"

"This is a very cruel reality." Wu Mian did not continue this line. "Doctor Coley felt that he had discovered the wealth code. I can imagine his excitement at the time. In April 1891, a desperate person Zola, his patient, became a volunteer, ready to try a new treatment."

"Because it was an experimental treatment, it was carried out in an apartment. Dr. Colley injected Zola with beta-hemolytic streptococcus. According to records, Zola was tossed and half-dead. But two weeks later, there was a neck tumor. Disappeared, he was healed."

　　 "Uh..." Yun Lan felt that this was beyond her own awareness.

　　B-type hemolytic streptococcus is so effective?

　　 is so effective!

　　Can you try it yourself? If the Southern University Affiliated Hospital is not good enough, brother bought several laboratories for himself overseas.

　　 Yun Lan was greatly moved when Wu Mian said this. But he "woke up" in a flash and laughed blankly.

　　 This is the method more than a hundred years ago.

　　" After that, Zola lived healthy for another 8 years. This experiment gave Corley hope.

　　 Within two years of Zola's recovery, Colley had carried out "infection treatment" for a total of 12 patients. "

　　 "But the effect is not satisfactory. I think the data in Dr. Colley's record is full of water. Of the 12 patients, 6 of the tumors were relieved, 2 were cured, and 2 died of infection."

　　 "Why is there water?" Yun Lan asked.

"For the treatment of advanced tumors, this probability cannot even be achieved by modern science and technology. Dr. Colley 130 years ago would be dissatisfied? I don't think so. And I repeated the experiment on mice. Unfortunately, I injected B. A 97.8% probability of a mouse with Streptococcus hemolyticus will die because of the infection."

　　 "……"

　　" After repeated experiments, the department replaced the original live bacteria with two inactivated bacteria, namely Streptococcus pyogenes and Serratia marcescens.

　　 Among them, the latter can enhance the effectiveness of the former, so that the injection can cause the effect of hyperthermia. At the same time, inactivated bacteria also greatly reduces the risk of death from infection. This bacterial mixed vaccine is what modern days call "Coli's toxin"

　　 "The pharmaceutical company Parker Davis at the time cooperated with Coley to provide doctors with Coley toxin preparations from 1899 to 1951."

"Modern medicine is evidence-based medicine. Dr. Kohli felt that it was useless. He had to find a clear chain of evidence to convince others. But after World War II, when Kohli was trying to find evidence, cancer radiotherapy began to become popular. NS.

Although 　　radiation therapy has always been regarded as "killing the enemy eight hundred and destroying one thousand", it has an effect that is visible to the naked eye for almost every patient. "

　　 "From the beginning of chemotherapy and radiotherapy, Dr. Coley was considered a civilian quack, but he has a daughter, and his daughter has been collecting evidence. Until later, it is the modern version of immunotherapy as you know it."

　　 "The process is so complicated."

　　 Yun Lan did not expect that immunotherapy would involve the efforts of two generations.

　　"Well, the principle has not been fully understood so far. To commemorate this "father of tumor immunotherapy", the highest honor of tumor immunology is also named "William Coley Award."

　　 It is worth mentioning that the Chinese oncologist Lie Ping won the 2014 Coley Award for discovering the pathogenesis of immune tolerance cancer. "

　　 "By the way, in addition to tumor immunity, there is another possibility that is happening to the oldest patient in our Fangcang shelter hospital, and that is-oncolytic virus."

　　 "If it is true, then the new coronavirus may have the potential to become an oncolytic virus."

　　 "The literature report on tumor regression after infection with the virus first appeared in 1904. Dock was the first to report a case of a 42-year-old female leukemia patient who was infected with influenza virus and the leukemia was in remission."

"In 1912, the Italian doctor Depace reported a case in which a patient with advanced cervical cancer had spontaneously subsided and shrunk after being vaccinated against rabies. The woman with cervical cancer was bitten by a dog and was vaccinated against rabies. There After that, cervical cancer began to shrink, and everyone thought it was a miracle."

　　 "Uh... Teacher Wu, I've heard of it."

"The success of genetically engineered oncolytic viruses for tumor treatment was first seen in 1991." Wu Mian ignored Yun Lan's words and continued, "Up to now, the most successful oncolytic virus is type 5 recombinant human adenovirus. , Used for the treatment of esophageal cancer."

　　 "Teacher Wu, do you mean that the new pneumonia virus has the potential to treat cancer?!" Yun Lan asked in shock.

　　"I just gossip with you~www.wuxiaspot.com~ Wu Mian smiled, "The new pneumonia virus is a typical ‘wild’ virus. It happens to have an effect on a certain cancer patient, but there is no way to promote it on a large scale. Therefore, this cancer patient can only be considered lucky. "

lucky……

　　 Yun Lan, as a doctor of medicine, finds it difficult to accept such words.

　　 But Ms. Wu Mianwu has explained it in detail, but Yun Lan didn't know how to refute it for a while.

　　 "This patient will leave it to you to record the changes in his neck swollen lymph nodes every day. You can tell him that his cancer is getting better. I think this is good news for the Fangcang shelter hospital."

　　 "Ms. Wu, what if the patients say that the new pneumonia virus can treat cancer and cause some cancer patients to take the initiative to contact the source of infection?"

"No way." Wu Mian said affirmatively, "Usually it is done with the attitude of a dead horse as a living horse doctor. It is difficult for similar patients to reason with them. I met a patient who took Oral wolf toxin. The dose exceeds the dose of traditional Chinese medicine by about 10 times, which directly defeats the immunity and causes the death of the patient."

　　 "……"

　　 "You should explain to the patient that if you don't go to your brother Lu, you need good news now, and this is good news."

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