Sleepless Doctor

"The Chinese Exclusion Act keeps mentioning mining, because at that time the profitability of mining was the same as the current chip. More than a hundred years have passed, but nothing has changed." Wu Mian finished speaking and put away the B-mode ultrasound. Probe, wipe the couplant on Gelbin Mekkatork's body with a tissue.

"Mr. Gelbin Mekatok has no major problems with abdominal organs," Wu Mian said. "Although his liver tends to accumulate fat, it is not important."

"Then what?"

"Go for NMR." Wu Mian said, "Mr. Gelbin Mekatok's autoimmune antibodies are all negative, and it is not caused by autoimmune encephalitis.

Excluding these diseases, if the MRI data does not show frontal and temporal lobe atrophy, we can go for a cup of coffee and wait for the last test result to come out. "

Owen Rothschild pushed the wheelchair silently, following Wu Mian.

Now that I have chosen to come to China to see Wu Mian for treatment, I still have the most basic trust. Even if it was Wu Mian's repeated denial, denying that Geerbin Mekkatorque was a mixture of goblin and Bigfoot.

An hour later, Wu Mian pointed to the image on the operating room screen and said, “Owen, Mr. Geerbin Mekatok’s brain shows no signs of shrinking, and his physical condition can be said to be quite good.”

"Huh?" Owen looked at Wu Mian, waiting for what he would say next.

"But the MRI showed that there were symmetrical abnormal signals at the bilateral internal capsule knees, bilateral internal capsule hind limbs, bilateral cerebral feet, pons, and cerebellar dentate nucleus. Owen, I will simply say that the images suggest that there is a problem with the brain, but it is not Alzheimer's disease."

"..."

"MRI of the ankle joint showed fusiform enlargement of the Achilles tendons on both sides." Wu Mian said, "here is the problem."

"Wu, if I didn't understand it wrong, can I say so." Owen Rothschild said cautiously, "Because Gerbin Mekkatork has a problem with his feet, his mental state is abnormal. ?"

When he said this, Owen felt extremely absurd in his heart.

Because of the problem of the feet, the brain is not easy to use... Is this really human words?

But Owen nodded when he saw Wu Mian, "Owen, you are really a smart man, what you said is right, that's what I mean."

"..." Owen was silent.

"The speed of genetic testing is very slow, and we still have a few hours." Wu Mian said, "I suspect that Mr. Gelbin Mekatok has a very rare genetic disease-brain tendon yellow. Tumor disease."

"Tendinoxanthomatosis?!" Owen didn't understand what kind of disease it was. He was very unfamiliar and had never heard of it.

"According to the name, you can know what the disease is. Brain tendon means brain and tendon."

"..."

It is difficult for Owen Rothschild to connect these two organs.

"This rare lipodystrophy disease. Generally speaking, it is recessively inherited and is characterized by progressive ataxia, dementia, cataracts and tendon xanthomas."

"Usually caused by mutations in the CYP27A1 gene, the worldwide incidence rate is one in a million, and the incidence is different in different regions. There are few reports in our country."

"Are you sure?" Owen Rothschild asked.

"Uncertain, of course not sure, it's just a guess now." Wu Mian said, "We are waiting for the results of genetic testing."

"It's really just a disease? Why can the brain and the feet be connected?" Owen asked.

"Patients with tendon xanthomatosis cannot convert cholesterol into bile acid. Another metabolite of cholesterol, cholesterol, will increase and accumulate in the body. On the other hand, the lack of bile acid causes negative feedback to lead to cholesterol. Too much generation."

"Wu, I know this can explain the **** cholesterol rise." Owen said, "But this can't explain the changes in the nervous system at all. Are you kidding? This joke is not funny at all."

"Owen, there is no definite conclusion about how Xanthelasma tends to cause neurotoxicity and damage the nervous system. However, some people have put forward the hypothesis that large amounts of cholesterol and cholesterol will damage the blood-brain barrier and cause the central nervous system. Nervous system is damaged." Wu Mian said.

"Perhaps you are not satisfied with this explanation, let's wait." Wu Mian saw Owen being silent, and continued, "If the genetic test results confirm my guess, even if you don't want to believe it, you can only accept this diagnosis. ."

"Can I trust you?" Owen Rothschild looked at Wu Mian cautiously, and asked word by word.

"You don't need to believe me, everything is based on objective examinations," Wu Mian said, "The information is complete before the last piece of the puzzle. You can send all the examinations to doctors in any hospital in the world for consultation."

"Wu, I trust your judgment." Owen's voice was low, and it sounded a little far away, as if it were a sound from a wall.

"Owen, this is science~www.wuxiaspot.com~ Wu Mian said, "Mr. Gelbin Mekatok's physical signs also prove this. Seventy percent of patients will develop tendon xanthomas, and neurological symptoms appear later, with various manifestations, including dementia, behavioral abnormalities, ataxia, pyramidal tract signs, epilepsy, spinal cord lesions, and peripheral neuropathy. "

Owen Rothschild was silent.

Wu Mian didn't say anything anymore, uploading the image data, turning off the machine, and leaving the nuclear magnetic room with Owen to wait for the final inspection result.

Not surprisingly, the inspection returns confirmed Wu Mian’s guess that Geerbin Mekatok’s CYP27A1 gene mutation.

"Owen, I will send all the information to your mailbox." Wu Mian said seriously, sitting in front of the inspection table, "I regret to tell you that Mr. Gerbin Mekatok's diagnosis is very clear. , It’s Xanthelasma of the Tendons. According to your description, when you were at Harvard, the doctor wanted to make a clear diagnosis, but you and Mekkatorque..."

Wu Mian sighed as he spoke.

"Wu, how should I treat it?"

"Give it a try. Generally speaking, the earlier the treatment, the better the effect." Wu Mian said, "Mr. Gelbin Mekatok should be given chenodeoxycholic acid neutralization treatment. The specific effect depends on the sensitivity of his body. Degree. But I judged by combining various materials, and I feel that there should be no problem."

"Can you sober?" Owen had new hope.

If Gelbin Mekkatorque could wake up, that would be a great thing.

"In terms of probability, there is an 85% probability." Wu Mian nodded and said, "Tendinoxanthomatosis is a progressive disease, but it is not fatal. Even if it is not treated, you may live to 50 or 60 years old. But early Finding that early treatment is more conducive to controlling neurological symptoms and easier to recover."

As he said, Wu Mian paused.

"It's okay, you have money, as long as you have money, you can solve it!"