The rise of nanometers

There is a reason why there is a disaster.

If you have seen the outbreak areas of African swine fever, you will find a very strange phenomenon, that is, small farms generally have no way to resist swine fever, but large breeding companies can use equipment sterilization and feed control to ensure that swine fever is difficult to resist. spread to their farms.

When swine fever completely wipes out small farmers, the market will be monopolized by the remaining breeding giants.

Whether intentional or unintentional, the emergence of swine fever has indirectly promoted the rise in pork prices and market monopoly. This is an undoubted fact.

If you are the boss of a large breeding company, are you willing to fund scientific research institutions to launch vaccines? This may be a big question mark.

It is better to rely on the conscience of capitalists than to trust in the immunity of pigs themselves.

In the case of a major outbreak of swine fever, some people can poison for profit. The large breeding companies do nothing but follow the trend.

If you have a darker heart, you can also spend money to lobby scientific research institutions to keep the vaccine in the "dystocratic" stage.

There is no end to human greed and evil.

Huang Xiuyuan has learned a lot of inside information, and there will be many related decryption studies in the future. The reason why this matter was exposed is because of the competition between natural meat and artificial meat in the future, and the two sides are digging each other's dirt.

Artificial meat companies have exposed the background of breeding groups, including swine fever.

The exposure of this incident also forced scientific research institutions to "rapidly develop" a swine fever vaccine.

Huang Xiuyuan had also read the papers from a dozen scientific research institutions at that time. He turned around and said, "Wen Cang, let's go to the genetic testing room and have a chat."

"OK."

Through three negative pressure gates, the group arrived at the genetic testing room. Li Wenchang and several researchers pulled up the gene sequence, protein structure, and cryo-electron microscopy images of the swine fever virus on the computer.

Huang Xiuyuan flipped through the relevant content. There are certain differences between the swine fever virus of this era and the swine fever virus of the future in the 1950s.

This is a normal phenomenon. Viruses are organisms that mutate very quickly. Mutations may occur during each RNA replication process.

In the span of forty years, there must have been a lot of changes.

He looked through the genetic sequences in the laboratory and found that the African swine fever currently prevalent around the world has two genotypes, type 1 and type 2.

The laboratory has carried out sampling and cultivation, as well as related genetic testing and vaccine development.

According to his future memory, in future related research, the African swine fever virus will be reclassified according to genetic characteristics into 101, 102, 103, 104, 201, 202, 203-1, 203-2, 204, and 205, in total 10 small branches.

The reason for such fine division is that the genetic and protein differences make it impossible to develop a universal vaccine.

Huang Xiuyuan spent more than two hours reading the genetic sequences of 36 samples and found that there were three small variants that were not included in the detected sequences.

In this case, there are usually only two possibilities, either the variant has not been born, or the variant has not been detected.

But the lack of those three variants did not have much impact on his subsequent arrangements.

Among the 10 variant genotypes of swine fever virus, they can be divided into three major types. The main basis for distinguishing them comes from gene fragment 47 in swine fever virus. This fragment contains 54 gene sequences.

This gene fragment is also the key to developing vaccines. However, future swine fever vaccines will all be RNA recombinant vaccines, not traditional inactivated vaccines.

At present, RNA recombinant vaccine technology is not yet mature. Although many domestic scientific research institutions are working on it, they are still clearly unable to make recombinant vaccines.

If it is an ordinary thing and the new product is immature, you can still put it on the market and give it a try; for a vaccine, if the technology is immature, if you put it on the market and give it a try, something big will happen.

Even if it is a pig vaccine, you cannot take risks casually. If the vaccine mutates in pigs and develops characteristics that can infect humans, the gain will outweigh the loss.

In Huang Xiuyuan's memory, he has seen Westerners fail several times in succession when it comes to RNA recombinant vaccines.

There was no way to use RNA recombinant technology, so traditional inactivated vaccine technology could only be used. According to the paper information in his memory, he knew that the focus of vaccine development for swine fever virus was on fragment 47.

On the computer's genetic map, he found this fragment. This fragment currently has no name. Fragment 47 is the future name.

Use a pen to circle four of the gene fragments, which were all the fragments that were focused on in the vaccine research and development papers at that time.

"Ask Cang, focus on the proteins corresponding to these four gene fragments."

Li Wenchang suddenly looked at each other with some confusion, and secretly sighed inwardly. As a professional biological virus expert, he did not think that Huang Xiuyuan was qualified to guide him in the research of virus vaccines.

In the process of scientific research and development, the most feared thing is for laymen to guide experts. When Li Wenchang was at a large domestic research institute, he encountered a half-full female director who didn't know how to pretend to know how to give directions everywhere.

Huang Xiuyuan may have seen Li Wenchang's worries. Before the other party could speak, he smiled and said, "Although I haven't studied viruses and vaccines in depth, I still know a little bit about them."

Li Wenchang has also been working in a state-owned research institute for more than ten years. He still knows a lot about the world and quickly explained: "Chairman, I don't..."

"Okay, let's talk about how to develop it." Huang Xiuyuan did not explain, but planned to prove it with his strength.

Li Wenchang, who was riding a tiger but couldn't get off, could only bite the bullet and start a discussion with him.

In the next more than three hours, researchers Huang Xiuyuan, Li Wenchang and other researchers started their discussion on African swine fever, and also extended to inactivated vaccines, genetic testing, RNA recombination, macrophages, etc.

At the beginning, Li Wenchang was able to do it with ease and found that the chairman's level was good. However, as time went by, he felt more and more strenuous and shocked.

In the end, it was Huang Xiuyuan who was guiding them, and they could only ask questions from time to time. Li Wenchang was in a daze, as if he had gone back to when he was studying in Gaul, working on a project with his tutor, feeling inferior and confused.

Unconsciously, his notepad was filled with more than ten pages of notes.

"Okay, that's it for today." Huang Xiuyuan pointed to his watch. It turned out that the time was already one o'clock in the morning.

Li Wenchang woke up and said with some shame and reverence: "Chairman, thank you very much for your guidance. It was me, Yelang, who was arrogant just now."

Other researchers also looked ashamed, and at the same time recognized Huang Xiuyuan's ability in viruses and vaccines.

It is not as difficult to identify a person's ability in the field of scientific research as it is in the field of literature and art. As professionals, Li Wenchang and others recognize Huang Xiuyuan's ability, which must be true.

On the way to see Huang Xiuyuan away, Li Wenchang lost his previous arrogance and only had respect and admiration.

Seeing that he was approaching the dock, Huang Xiuyuan stopped and said: "Wen Cang, among the four fragments, I am optimistic about fragment 2. You can try to inactivate the virus. When it comes to RNA recombination technology, be cautious and don't act too hastily. "

"Chairman, please rest assured, I will pay more attention." Li Wenchang knew the dangers of RNA recombinant technology, so naturally he did not dare to be careless.

"Go back and rest!"

"Chairman, take care!"

The ferry's diesel engine roared again and soon disappeared into the night.