The rise of nanometers

The turmoil in Northeast Asia has not had a significant impact on the country. As the Suiren system that promotes changes in the situation, it still appears to be calm.

When Huang Xiuyuan received the news about the establishment of Samsung in China, he didn't pay much attention to it. Instead of pinning his hopes on these trivial things, he might as well seize the time and develop more new technologies.

After instructing Lu Xuedong, Zhang Jingjian and others to continue studying the 12-nanometer process of textile methods and three-dimensional chip technology, he went to Luhe County in Shanmei.

The headquarters of Shennong Group and six core laboratories are located in Luhe County.

Shennong Group has been established for more than a year. In addition to the pharmaceutical research and development, vaccine research and development and medical equipment research and development that it took over from Fenmin Agriculture and Snail Industry, it has also successively poached a lot of talents from domestic enterprises and the Academy of Sciences in this year. people and established their own scientific research system.

The president of Shennong Group is Zhao Xiaojun, who was previously the head of the Blue Era Shandong branch, and the chief technology officer is Mo Siqian, who was poached from the Academy of Sciences.

About three kilometers east of Luhe County is the vast headquarters of Shennong Group, and the six core laboratories are inside the mountain of the headquarters industrial park, or hidden underground.

When you come to the beautiful Shennong Group, if it weren't for the Shennong Group Industrial Park sign, it wouldn't look like a large medical company, but rather like a large agricultural industrial park.

Various professional greenhouses cultivate a variety of plants and some special animals.

The three office buildings at the headquarters have dense sky gardens on the roof, the walls are covered with solar panels, and the complex underground buildings are like Umbrella's honeycomb base.

After changing their protective suits, Zhao Xiaojun and Mo Siqian took Huang Xiuyuan into the underground scientific research base. There are two top virus laboratories here. In order to ensure safety, layers of isolation layers are essential.

In the two virus laboratories, RNA vaccine technology, swine fever vaccine, Ebola vaccine, HIV vaccine, cancer vaccine and so on are currently being studied.

After passing through the disinfection area several times, Huang Xiuyuan turned around and asked: "How is the progress of the swine fever vaccine?"

"It's almost ready for promotion. At present, the adverse reactions of the swine fever vaccine have reached the lowest, the fatality rate is about 1.2 per 10,000, and the two-shot protection rate is about 98.6%." Mo Siqian answered truthfully.

Huang Xiuyuan thought for a while and said: "Since the effect is so good, after completing the final testing work, we will promote it internally."

"Understood." Zhao Xiaojun nodded.

After talking about the swine fever vaccine, they came to the first laboratory, which is a medical laboratory of nanomaterials.

Nanotechnology is the specialty of the Suiren family. Naturally, Shennong Group did not abandon the good and pursue the bad. Instead, it invested heavily in in-depth research on the application of various nanomaterials in medical treatment.

In the laboratory, a scientific research team demonstrated the medical application of gold nanorods to Huang Xiuyuan.

A white pig suffering from early-stage lung cancer was injected with gold nanorods combined with a targeted targeting agent after being anesthetized.

Under an electron microscope, gold nanorods are tiny particles with a length of 15 nanometers and a width of 3 nanometers.

When the directional targeting agent carries gold nanorod particles and enters the lungs of the white pig along with the blood circulation, this directional targeting agent is a mimetic amino acid substance. Cancer cells specifically absorb this mimetic amino acid and incidentally absorb those gold nanorods. Also "eat" it in.

On the computer, the researcher started the near-infrared light illumination system, and a CT-like image of the white pig was immediately displayed, with light spots flashing in some areas.

The reason why this contrasting picture appears is that gold nanorods are very sensitive to near-infrared light and can easily reflect light, while ordinary cell tissues do not scatter near-infrared light.

Low-power near-infrared light can produce a very obvious light reflection imaging effect, which is more accurate and clearer than ordinary tumor imaging, and is less likely to harm the patient's body.

On the imaging screen, Huang Xiuyuan could clearly see the malignant tumor cells entrenched in the lungs of the white pig.

If it is just a harmless imaging, it is not enough for researchers to take it so seriously.

This involves another physical property of gold nanorods, which is the ultra-high photothermal conversion efficiency. Once relatively high-power near-infrared light shines on the gold nanorods, the gold nanorods will convert the light into heat.

So what is the use of this physical property?

The answer is to precisely kill cancer cells in the body.

On the experimental platform, a beam of near-infrared light irradiated the ordinary cell tissue of the white pig. At most, it felt slightly warm and did not cause any harm.

But those cancer cells that devoured the gold nanorods seemed to be burning like fire. The gold nanorods crazily absorbed near-infrared light and quickly converted the light into heat energy, raising their own temperature to several hundred degrees Celsius.

This temperature is enough to cause a devastating blow to the cells of carbon-based organisms.

The lung cancer cells in the white pig's body were burned to death one by one, and the gold nanorods quickly disintegrated into gold atoms, losing the nanorod structure with high photothermal conversion rate.

After twenty minutes of killing, the white pig's lungs and spreading cancer cells were all strangled. Through multiple enhanced CT scans, everyone can clearly see that the positions representing cancer cells have appeared in the contrast image. Obvious cellular deterioration.

Mo Siqian introduced him in a low voice: "Chairman, in our animal experiments on gold nanorods, whether it is special cell imaging or targeted photothermal inactivation, we have achieved perfect results."

"How toxic is the gold nanorod contrast agent?" Huang Xiuyuan asked.

"Chairman, please rest assured that the physical properties of gold are stable. After gold nanorods are decomposed into gold atoms, they will be excreted from the body within a week. Only very few gold atoms will stay in the body for a long time."

Huang Xiuyuan is very satisfied with the effect of gold nanorods.

You must know that the most feared situation in current cancer treatment is the spread and metastasis of cancer cells. Once cancer cells spread throughout the body, it is basically a death sentence.

Common chemotherapy or radiotherapy can cause serious harm to the patient's body, and may even cause pain worse than death.

Chemotherapy is the use of chemical drugs to kill cancer cells, which are three parts poisonous. Cancer cells are inherently powerful cells, and drugs that can kill cancer cells are naturally not good at killing normal cells as well.

Radiotherapy is radioactive therapy, even if it uses the most advanced heavy proton therapy, it will affect some normal cells.

The photothermal killing of gold nanorods developed by Shennong Group has a much smaller impact on normal cells than heavy protons.

More importantly, gold nanorods can deal with proliferating cancer cells.

The equipment cost is not too high. The main cost is concentrated on the targeting particles of gold nanorods. According to the size of the lesion, the dose can be divided into 12 levels, with one unit dose per level.

On average, a unit dose of gold nanorod targeting particles costs about 1,200 yuan. Even if it is mass-produced, the cost will not be less than 800 yuan per unit.

Fortunately, the therapeutic effect of gold nanorod targeted particles is very good, better than heavy protons.

You must know that the current heavy proton equipment costs more than one billion, and it needs to be imported from abroad. The price-performance ratio between the two is simply different.

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