The rise of nanometers

The chief researcher in charge of the fluorescent fungus gene embedding project is Dr. Chen Gexin, a former genetic engineer in the military with a Mediterranean hairstyle.

Huang Xiuyuan said with a helpless expression: "Old Chen, you experimented 358 times on gene insertion in mice, and only two mice developed benign mutations. There is still a long way to go!"

Watching the researcher operate the robotic arm to extract some cell tissue from the struggling mutant mouse.

Dr. Chen Gexin turned his head and spread his hands and replied: "There is nothing I can do. This ghost mutates too fast. Once it enters the body, it will undergo all kinds of strange mutations. It is difficult for me to determine the stable gene sequence."

Huang Xiuyuan also tried hard to recall the high mutation speed of the Yinghuo fungus, and countless memories were flipped through his brain.

In fact, after the biochemical crisis in later generations, until he was assassinated, mankind failed to successfully lock the safe gene sequence of the fluorescent fungus.

Even if nanorobots and nanomicrocomputers are used and added to the human body system, it is still difficult to suppress the "negative optimization" of fluorescent fungi on the human body.

As for the situation behind the scenes, he had some gossip in China, but the strongest force in genetic technology at that time was the Noah Society.

Naturally, Huang Xiuyuan would not easily know about Noah's secret research project in biotechnology.

Suddenly, two papers appeared in his memory, namely:

"Stabilization and mutagenesis of the MES-63-K53 gene fragment of the Mars fungus" published in 2052, author Andrew Marshall, Deutsche Institute for Biological Research;

The other article is "Special Genetic Structure of MES Fungi" published in 2056, written by Oda Tai'an, Japan's Third Biochemical Laboratory.

Among the many papers related to fluorescent fungi, Huang Xiuyuan noticed these two mainly because other approaches did not have many obvious results.

Turning on the computer, he turned on the supercomputer assistance period, and called up the gene sequences currently detected by fluorescent fungi, as well as the gene sequences of more than a dozen mutant fluorescent fungi.

When Chen Gexin saw Huang Xiuyuan looking thoughtful, he didn't dare to disturb him. He just watched quietly and looked at the genetic simulation model in the computer.

Fluorescent fungi also share the genetic sequence of a double helix, but due to their high mutation characteristics, each individual of these mutated fluorescent fungi does not have a large number of identical gene segments.

According to ordinary microorganisms, even if their genes mutate quickly, they will not change beyond recognition.

The fluorescent fungus violates this situation. After a mutation, a large number of gene sequences will basically show varying degrees of mutations.

It is this almost ever-changing characteristic that leaves many researchers at a loss.

In these two papers, a special genetic framework was analyzed through another model. In the genetic sequence of a mutated fluorescent fungus, he marked 117 sets of genetic sequences in red fonts based on that specific model. come out.

Then came the second mutated fluorescent fungus, the third, the fourth...

Standing aside, Chen Gexin felt confused at first. He could not see any special patterns in the marked gene sequences.

But as the genes of mutated fluorescent fungi were entered one by one, he seemed to see some tricks in it.

After marking more than twenty mutated Yinghuo fungi, Huang Xiuyuan turned his chair and asked with a smile: "Old Chen, do you see any patterns?"

"There seems to be some pattern..." Chen Gexin seemed to have caught something, but it was like seeing flowers in a fog.

Huang Xiuyuan solved the mystery: "Look, here, here..."

He pointed to the gene sequence and systematically circled 15 different groups of bases, and then continued: "They seem to be different, but in fact, if you remove the two base pairs from the head and the tail, see what happens. Isn’t it exactly the same?”

"Huh? They're really exactly the same." Chen Gexin suddenly realized: "It's interesting."

The two collaborated to verify and found that once the first and last base pairs of these base groups are removed, these gene sequences form an inconspicuous and impregnable genetic structure.

"Obviously this is a breakthrough point. Sometimes we can't look at the Yinghuo fungus with the eyes of Blue Star."

Chen Gexin nodded: "Yinghuo is from Mars, and it may indeed be different from Blue Star."

If the fluorescent fungus is really different from Blue Star's biological genes, then they need to consider this issue.

"We can actually prepare an experiment to test these architectural genes."

Huang Xiuyuan asked curiously: "Old Chen, how do you plan to experiment?"

"It's very simple." Chen Gexin took out a ballpoint pen and drew a double helix gene sequence on the scratch paper: "If I destroy or replace these architectural genes through transgenic technology, there are often only two possibilities in this case. "

After a pause, Chen Gexin continued: "In the first case, after the transgene, Yinghuo repaired the transgene himself, or there was no change in himself, which proves that the so-called framework gene is fake."

"In the second case, after transgenesis, the Yinghuo will self-disintegrate and it will no longer be able to achieve high-speed mutation."

After hearing the experimental design, Huang Xiuyuan immediately agreed. This experiment can indeed preliminarily determine whether the fluorescent fungus has a framework gene.

Soon, the materials, equipment, and manpower for a genetically modified experiment were ready.

With an order, the researcher operated the robotic arm and began to carefully conduct transgenic experiments on the fluorescent fungi.

Through electron microscopes, Huang Xiuyuan and Chen Gexin saw those fluorescent fungi. Among them, the fluorescent fungi whose structural genes had been changed showed a half-dead state.

However, other genetically modified fluorescent fungi that have not touched the framework genes are still active and active.

"Obviously this is the core gene of fluorescent fungi that we have been looking for." Chen Gexin said enthusiastically.

Huang Xiuyuan shook his head: "The experimental data is not enough. You must find all the suspected architectural genes one by one."

"I understand that we will continue to arrange manpower to identify all the architectural genes."

After finally finding a way, Chen Gexin and others will naturally not miss it.

However, Huang Xiuyuan is not blindly optimistic, because in his memory, the reason why this model has not become mainstream is mainly because the model is missing a part.

The missing part is not that the author deliberately concealed it, but that the other party also found nothing.

When this plan came out, it indeed attracted great attention from the academic community, but all gene insertion experiments ended in failure.

After supercomputer simulation calculations, the academic community found that there were some deficiencies in this plan, but they have been unable to find specific flaws, resulting in the embedding experiment being unable to be realized.

Huang Xiuyuan did not remind Chen Gexin because he knew that the other party would encounter this matter sooner or later, so he will not spoil it.

What's more, he is also thinking about what is the missing part in the genetic model?

Chen Gexin immediately took action and began arranging manpower, materials, and equipment to prepare for a big fight.

In the research related to fluorescent fungi, the leaders of each project do not work behind closed doors. They will conduct regular academic exchanges.

This time, the discovery of the architectural gene was soon known to other project leaders, and they were also evaluating it.

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