I can extract side effects

On this day, all users who had uploaded cases on Longtu APP received a system message.

"Dear users, Longtu's latest function 'Sharing Lab' will start trial operation tomorrow. Due to limited conditions, only the lab in Kunming City is currently open. Users who need it are welcome to experience it."

For most users, this is just an ordinary, unremarkable push.

Although they are also patients, they can buy medicines for treatment from medicine, so they don't understand the meaning of this news at all.

Many won't even open it, let alone click through to see the 'Shared Lab' feature.

But for other patients, it's a completely different story.

To them, this news was like a sound of nature, and it was the good news they had been waiting for for a long time.

A patient group called Copper Doll Self-Help Group has about 200 to 300 members.

At this moment, the crowd was boiling.

"@带头大哥, the shared laboratory is ready. Are we going to start working!"

"Group leader, everyone is waiting for your news."

"Fortunately, the group leader is in Suzhou City, not far from the laboratory in Kunming City, so he will definitely be able to catch up with the first wave of experience."

The group leader took the lead and the big brother quickly appeared. He didn't say much, and his reply was simple and clear.

"It's ready, everyone, don't worry, everything is by me."

At the same time, a screenshot was thrown out, it was he who ordered the three-hour shared laboratory order on Longtu.

The group of friends immediately applauded enthusiastically.

"As expected of the leading brother, we are waiting for good news from the big brother."

"Brother, can you come to a live broadcast tomorrow? I want to learn."

"Brother is awesome, I will always follow in his footsteps!"

The eldest brother who takes the lead is a person who cherishes words like gold, and the second sentence has only one word: "Okay."

Then there was no more sound.

The group of friends are also used to his diving, and they exchanged ideas about their children's condition.

The elder brother who took the lead put down his mobile phone, got up and walked to the study room. On the desk inside were some preparation materials he bought, the most important of which was a small bottle of raw materials. Others included disposable latex gloves, medical masks, capsule shells and medical starch, etc. .

He is a parent of a copper doll patient, and he is going to inspect the newly opened shared laboratory tomorrow to see if he can use the equipment inside to make some trientine hydrochloride capsules.

Trientine hydrochloride is a copper ion complexing agent, its effect is similar to that of penicillamine, it can promote the excretion of copper through the kidneys, so as to remove excess copper in the body, and is used for hepatoloids that are intolerant to penicillamine Patients with nuclear degenerative venereal disease, also known as copper doll Wilson's disease.

Wilson's disease is a rare genetic disease characterized by copper metabolism disorders caused by chromosomal abnormalities. The worldwide prevalence rate is about 1 in 30,000. Left untreated, it can lead to fluid buildup, jaundice, nerve problems, and fatal kidney failure.

Fortunately, there are effective treatments for this disease. The commonly used drugs are penicillamine (Cuprimine) and trientine hydrochloride (Syprine), which must be taken for life.

Since trientine hydrochloride came out in the 1980s, the patent has long expired, but there has been no domestic pharmaceutical company to develop generic drugs, and foreign original drugs have not been marketed in China, and the price is very expensive, about 200 US dollars a piece.

The eldest brother’s son needs this kind of medicine to treat his illness. Before that, he asked someone to buy it from abroad. Later, because the burden was too heavy, he came up with the idea of ​​making this kind of medicine.

The manufacturing process of trientine hydrochloride is simple, and it is not too difficult to make it yourself. The leading brother himself is also an intellectual. After a period of hard work and self-study, he has mastered a certain amount of chemical and pharmaceutical knowledge.

At the same time, he searched for various information on the Internet, bought relevant simple equipment, and purchased some raw materials from the manufacturer. After many exercises, he finally produced some trientine hydrochloride capsules.

After taking it to his son, he found that it could indeed achieve a certain effect.

However, after comparing with the original drug, the side effects and production process are still a bit worse.

So we can only continue to experiment and keep improving.

Later, after he registered Longtu, he found a lot of relevant professional information on the forum, and experts helped answer some questions. He made great progress. After some practice, the self-made medicine he made became more and more refined.

The patient groups he joined before were all family members of patients who needed this drug, and they all admired his behavior.

Everyone is yearning for it, but unfortunately, most of the family members are scumbags, and few of them have the energy to teach themselves to make medicines.

Not long after, the leading brother discovered the function of "Shared Lab" on Longtu. Although it hadn't been opened yet, this function flashed across his mind like a bolt of lightning, lighting up a spark called inspiration.

In fact, the conditions for his own pharmacy at home are very simple. Many equipments are not complete, and the environment cannot be completely sterile.

As a result, the finished product is far less effective than the original drug. Although he has been working hard to improve his proficiency and manufacturing process, he is not a professional with a professional background after all, so he is a bit powerless.

The part of the drug preparation that produces medicinal effects is called the raw material drug. The raw material drug cannot be taken directly. It needs to be weighed, proportioned, mixed with excipients and filled according to a series of strict processing procedures.

Every pharmaceutical factory must meet the GMP (Good Manufacturing Practice) standard to manufacture drugs, in order to ensure the final safety, reliability and risk control of the drugs.

If you can use professional instruments and equipment in a professional laboratory, and even have high-purity raw materials, then the manufactured medicine will naturally be more pure, and the efficacy will be closer to the original medicine.

After the leading brother figured it out, he told the patients in the group what he thought, and got unanimous encouragement.

He made a lot of preparations for this, and he also summarized and recorded all his experiences and compiled them into a book.

After the experiment is completed in the shared laboratory and the plan is confirmed to be feasible, other patients can make their own medicines according to this manual.

Now, everything is ready, just waiting for the shared laboratory to open.

And he wrote an article titled "Compilation of Drug-filling Tools, Side Effects Treatment, and Drug-filling Guidelines", which also guided the whole process of pharmaceutical preparation in detail.

This article has already been widely circulated among patients, and even thoughtfully attached detailed usage instructions and purchase links under each term in the guide.

Today, when he finally received the opening announcement of the shared laboratory, he was extremely excited and looked forward to it.

He has already made preparations, bought the raw materials, prepared the necessary consumables, and waited for tomorrow's experiment.

The next day, he got up energetically, drove to the industrial park in Kunming early in the morning, and found the address of the shared laboratory.

The laboratory is on the first floor of an office building, with a big sign: "Dragon Image Sharing Laboratory", the familiar red logo, and a dragon flying in the clouds are very eye-catching on the sign.

Looks like a pharmacy from the outside, everything looks new through the glass doors.

The elder brother who took the lead turned on the mobile phone, scanned the QR code on the Longtu APP to confirm, the door opened slowly, and he walked in curiously.

Once inside, there is a changing room, where there are lockers for personal belongings and changed clothes.

He put his phone and belongings in a locker and took out a plastic bag that was already in it.

Inside the bag were a white lab coat, a protective face shield with goggles, a pair of slippers, a pair of disposable latex gloves, and a white cap.

The leading brother took off his coat and leather shoes, put on a lab coat and slippers, and put on gloves and a mask.

When he was ready, he took out the raw medicine, pushed open the door at the other end of the locker room, and walked in.

Inside is a long corridor, with five small laboratories on each side, and a relatively complete large laboratory at the end of the corridor.

The elder brother who took the lead looked at the laboratory number, found the one he reserved, opened the door and walked in.

The lights turned on instantly, the small laboratory is not big, about 10 square meters, and there are all the common equipment in it.

He quickly found familiar utensils such as measuring cups, test tubes, medicine spoons, extremely high-precision electronic balances, weighing paper, sieves, mixers, medicine pounders and grinders.

Great, these things are all complete, and a gleam of joy flashed in his heart.

It's a pity that there is no way to take pictures or broadcast live, so I can only go back and dictate to the group of friends.

From his pocket, he took out vials of APIs, capsule shells, and medical starch, the latter two of which can be purchased online.

He brought 5 grams of raw materials for one month, 180 yuan per gram.

In order to prevent unnecessary loss, he concluded that tinfoil or oiled paper must be used to weigh and fill the powder, because if white paper is used, the powder will definitely stick to the paper.

After that, he followed the steps step by step, not daring to make any mistakes, and quickly completed all the familiar procedures.

Soon, it came to the last process of self-pharmacy: filling capsules.

Charging powder is serious physical work that tests patience.

Generally speaking, before filling the medicine, he will wear thin medical gloves to prevent his hands from sweating and sticking to the medicine.

Masks are also necessary. First, if you don’t wear a mask, you may get a red envelope on your face. Second, it prevents you from sneezing when filling the medicine.

Fortunately, everything has been prepared in the laboratory. He is fully protected from the beginning to the end. He is almost armed to the teeth and is very professional.

The tin foil on the electronic scale should be folded higher on the four sides to prevent the powder from falling. Then, weigh 1 gram of raw materials and 4 grams of auxiliary materials respectively, and then shake them vigorously.

Only by mixing thoroughly and evenly can such side effects be minimized.

He used a sieve of more than 100 mesh and two large sheets of tin foil to sieve and pour back and forth, and he had to do this more than 20 times each time.

Shaking until your hands are sore, you can carefully put the capsules in.

The straw picks up the powder and pours it into the capsule like a spoon.

A total of 30 capsules need to be packed, which is enough for a month.

It may even take four or five hours for a hand-made person to fill 1 gram of medicine.

And he is already very proficient, and he can fill a capsule in five minutes.

All capsules were packed and everything went well.

After stretching and stretching his body, he began to visit the laboratory.

These instruments and equipment are very strange to him, and he has the freshness and curiosity of a child seeing toys.

There is an operation desk in the laboratory, and several functions are displayed on the large screen, such as help, reservation, inquiry and so on.

"Hey, there is a pre-order function, click on it and try it, what? You can pre-order raw materials?"

The elder brother who took the lead was shocked, and quickly browsed through the entire list carefully.

Some common chemical raw materials are listed in it, but there are no dangerous substances.

There are also some raw materials that he is not familiar with, which are probably suitable for other diseases.

Soon, he found the raw material he needed at the bottom: trientine hydrochloride.

He was dumbfounded, too shocked to speak.

The service is also very good and considerate.

APIs are actually upstream of normal pharmaceuticals. Strictly speaking, APIs are not directly given to patients, because they are not medicines, but just like other chemical products, they are just raw materials.

Although it is legal to buy and sell APIs, it is still quite difficult to find purchasing channels.

It took a lot of effort to buy these raw materials in his hands. At the beginning, the sellers did not sell them to individuals, and he obtained them through informal channels.

There are a huge number of patients in China who buy raw materials like him, and the sales channels of raw materials are also very complicated, making it difficult to distinguish between true and false.

Most of these raw materials come from so-called scientific research institutes, laboratories, and pharmaceutical companies, and there are even some individual sellers.

Due to the different purity, the price is also different.

As far as he knows, the ones that sell more are produced by pharmaceutical factories, with large output, average purity, and cheaper prices.

However, the production of raw materials in the laboratory is small, and the purity is stable at more than 99.7%. They are not wholesaled, and they are only produced and sold in the name of scientific research. The price is very expensive, at least several times higher than the price of pharmaceutical factories.

Because the side effects of high-purity APIs are much smaller than low-purity ones, low-purity ones contain more impurities and heavy metals, which are toxic to the liver and kidneys, and tend to swell the limbs after a long time.

The raw material medicine bought by the leading brother is the highest precision on the market, with a purity of 99%, and the price is also the most expensive.

According to the seller, it was first-hand synthesized in a scientific research institute in Beijing, but when he asked which institute it was, the seller refused to disclose.

Of course, some raw materials may also be synthesized in private homes, which are generally small family workshops, and a set of equipment plus technology is only hundreds of thousands, the output is not large, and the purity is not high.

No matter what kind of channel it was produced in, they all turned into powders with exactly the same shape, and were sent to the hands of countless patients.

Take the lead and click to enter the page of trientine hydrochloride.

The details interface shows the molecular formula and synthesis method of the compound, and the purity is as high as 99.99%.

Below is the order button. After clicking, you will enter the payment page, and you can directly use the account of the scheduled laboratory to place an order.

The price is 80 yuan/gram, which is a great conscience compared to the price he bought from a drug dealer himself.

The elder brother who took the lead had trembling fingers, and he clicked several times before placing the order successfully.

The order shows that it will take three days to pick up the goods, and it can only be used in the laboratory and cannot be taken away.

But this is nothing to him at all. Anyway, he has to prepare it himself and take it away after making it into a finished product.

At this moment, he was pleasantly surprised. The function of this shared laboratory far exceeded his expectations and brought him a brand new experience.

His needs are extremely simple in such a professional laboratory.

Raw materials that were hard to find in the past are now available at your fingertips.

In the past, it was necessary to go overseas to buy expensive original research medicines, but now you can simply make them yourself.

This is heaven for patients like him.

Either the drugs needed by these patients are not on the market in China, only available overseas.

Or the imported medicines needed are too expensive to afford.

In the past, patients could only find ways to support themselves through various informal channels and make their own medicines.

Those drugs are not only not of high purity, but also produced in a substandard environment. They often have serious side effects and unclear efficacy. Many patients even delay treatment because of this, and doctors complain a lot about it.

However, there is no way, this is already the best choice for patients.

Now, they can have a place where they can buy high-purity raw materials, have a clean and standard laboratory, and can make some simple finished products, saving the lives of themselves and their families.

This undoubtedly greatly reduces the risk of self-medication.

This is really important to them.

When the leading brother returned home, the shock in his heart could not dissipate for a long time.

He opened WeChat, looked at the group of patients, and there were thousands of thoughts in his mind and thousands of words in his heart, but he didn't know where to start.