I can extract side effects

Chapter 528 Clinical trials of artificial blood vessels

"After the rabbit experiment was a great success, the brother was very confident and prepared for a while. He called me over again and started the production of human organs."

"However, the scaffolds we were growing on at the time were not man-made, but obtained from organs donated by donors, and the donor stems were washed with a mild detergent that does not damage the extracellular matrix. , but all donor cells can be removed."

"After two weeks, all that was left was a collagen scaffold of an organ onto which we implanted cultured cells taken from the patient, first smooth muscle cells and then vascular endothelial cells, which juxtaposed to form blood vessels. "

"Cultivation of cells took many months, followed by several failures, and it took more than a year to create the main body of a human organ under laboratory conditions."

"In addition, cultured patient skin cells were used as the outer wrapping skin, and a vein cut from the thigh was used to replace the urethra."

"The final product is very complete, with everything that should be there, but the size is relatively small, about the size of a finger."

"But in the functional verification stage, we encountered a big trouble, which is to suppress the immune response in the host patient."

"We first transplant the artificial organ into the patient's arm to see if it can get a good blood supply, and at the same time verify the hyperemia function of the cavernous body. If all goes well, after about a few weeks, it can be separated from the arm. Come out and do the follow-up transplant."

"Unfortunately, the experiment fell at this stage. The patient's immune system destroyed the artificial organ. At the same time, we also failed to verify the hyperemia function. After the spongy body received blood supply, it did not expand automatically, let alone the size we expected. .”

"After the experiment failed, we realized that there is still a long way to go. Human organs are far more complex than those of animals. Even if you make a structure that is exactly the same as a real organ, its functionality is difficult to guarantee."

There was a trace of regret in Ding Mian's eyes, and he sighed and said: "I left this experiment later and went on to other things. I don't know what happened to the senior brother and whether it is still continuing. In the past few years, there has been no clinical success. Maybe he also gave up research in this area.”

"It's really scary. We are very close to success, just a few small steps away. If it was really made at that time, it would be a sensational achievement in the world. Maybe I will join his laboratory and be forced to stay. It's over there."

Thinking of this, Ding Mian was obviously a little scared, and said while patting his chest.

"It's so dangerous. I was a bit over the top in this experiment. I forgot to hide my strength. I almost couldn't control the prehistoric power in my body. This exposed my true talent and attracted the attention of the mysterious organization of the Eagle Kingdom."

"As soon as the experiment was over, another team invited me to join their project. Damn, there must be a conspiracy to find me so soon. They must tie me, a genius, to a chariot and stay in the Eagle Kingdom completely. I can't go back to my country for the rest of my life."

"I broke out in a cold sweat. I was so careless. I forgot to hide my clumsiness, so I found an excuse and flatly rejected their invitation."

"Hey, the success of the animal experiment is all due to my carelessness. Fortunately, when I made human organs, I realized this and didn't make much effort. Although it was exposed a little, it was not completely exposed."

"It was only after the experiment failed that Eagle Nation turned its attention away from me, and I was able to graduate and return home without being accused of stealing secret technology and being imprisoned for the rest of my life."

Hearing this, Xue Shen couldn't help looking at Wen Renlong, and gave a veiled look: "Has he always been like this?"

Wen Renlong shook his head, and gestured calmly: "It's not like this often, only when we talk about this topic will we get sick."

Xue Shen nodded emphatically, and then he relaxed, and quietly gave Wen Renlong a thumbs up.

The two communicated tacitly, and Ding Mian finally completed his introspection.

He looked at Wen Renlong, with a look of compassion on his face, and said with a sigh.

"Brother Long, it is because I want to be wise and protect myself that this technology has been delayed. Over the years, although I have never regretted it, I always feel sorry for those patients."

"Think about men who have lost their self-confidence because of reproductive defects, traumatic injuries, or previous cancer surgery, and those who are transgender, who are full of hope, and this technology can completely change their lives."

"It's because of my selfishness that I made them suffer for a few more years. Fortunately, with you, Brother Long," he looked at Wen Renlong affectionately: "You fought hard and won this new project from President Wei. Thank you for these patients."

Wen Renlong's goosebumps came out when he saw him like this, his buttocks slid on the sofa for a while, and he immediately backed away one meter away.

"Don't you look at me like that, it's creepy. Come on, stop giving your speech and focus on your project."

"According to what you said, didn't the previous experiment fail? You can only do an animal experiment at most, and it seems that the success rate is not very high."

Ding Mian didn't take it seriously, and said with a chuckle: "It would be very difficult to make a complete human organ, and I'm not sure yet, but you are not, no, it's your friend, isn't it going to be augmented? This is much simpler."

"Oh, let me elaborate." Wen Renlong looked at him with fiery eyes, his face full of dissatisfaction with the desire for knowledge.

"Currently there are three ways in the medical field to change the size, one is lengthening through ligament plasty, one is implanting prostheses, and the other is filling with the body's own fat."

Ding Mian picked up the coffee calmly, took a sip, and frowned immediately: "The coffee is cold, it's really bad."

Wen Renlong snapped his fingers quickly: "Waiter, have another cup of hot American style."

Ding Mian put down his cup and explained in detail: "The ligament lengthening operation requires high qualifications of the hospital. If the technique is not superb, it will cause damage. Needless to say, implanting prostheses is usually done by extracting fat from the patient's abdomen. Injected into the organ, it can probably be extended by two or three centimeters, which is better than nothing."

Wen Renlong shook his head quickly: "Oh, what is better than nothing, you children don't understand, it is already very good to be able to extend it by two or three centimeters, and it is very useful."

Seeing the gazes of the two turning around in unison, he couldn't help blushing: "I'll just talk casually. Continue!"

Ding Mian coughed lightly, and said: "Maybe I didn't explain clearly enough, in fact, the length and girth both increase by two or three centimeters respectively. However, this method also has shortcomings, that is, some fat cells will be decomposed over time , but it’s not a big deal because the operation can be repeated, it just costs some money.”

"Just like breast augmentation surgery for women, there is actually a lot of room for demand for london surgery for men."

"In short, if your friend wants to have this surgery, you can find a qualified doctor in China to do it. It is a normal plastic surgery. There is no need to be a clinical guinea pig. After all, we still have a relatively high risk here."

Wen Renlong nodded thoughtfully: "Okay, I will persuade him, or try to perform a Longding operation first."

"However, if it is really small, or if the function is damaged, it is not very meaningful to operate."

"That's right, then we can only pray that our project will succeed as soon as possible."

Ding Mian reached out to take the coffee handed by the waiter, took a sip, and added with a trace of satisfaction on his face.

"Speaking of artificial organs, this is indeed a potential scientific research project. Artificial blood vessels, artificial bladders, artificial trachea, artificial urethra, etc., are actually similar in structure. As long as one is done, the others are not too different. Great technical difficulty."

"The artificial penis is really difficult, because it has certain functions, and the reproductive function is very important."

"Fortunately, it is only a part of the reproductive system. Compared with the main functional parts such as artificial uterus and artificial testicles, it is much less difficult."

"Understood, understood!" Wen Renlong picked up the coffee and touched the cup to it: "Then I wish you every success and rescue the suffering brothers as soon as possible."

The three chatted for a while, and then returned to the laboratory one after another to continue their work.

As soon as Xue Shen returned to the office, he got a piece of good news.

"Great, the clinical trial application for the artificial blood vessel has been approved."

"The fast track for innovative achievements is not bad. As long as the clinical trial results come out, the success of the project is a certainty."

He rubbed his hands excitedly: "Thinking about it, it's really exciting."

As soon as these words came out, he stopped, looked at his hands in astonishment, and was a little dumbfounded for a moment.

"Hey, this gesture of rubbing your hands is really like a big blowfly, and it's a particularly wretched one. How could I be infected with such a wretched gesture by him? It's really terrible."

*****

"Walking into the First People's Hospital of Kunming, why can you always see the confidence on the faces of doctors and nurses?"

"Why do they always have unwavering faith in the face of difficult, difficult and critically ill patients?"

"Why are the technologies that fill the gaps in China successfully completed here?"

"Next, let's go into a cardiac surgery operating room at two o'clock in the morning to find answers to our questions."

A female reporter appeared in front of the camera, introduced the program with a smile, and then, surrounded by photographers, walked into the brightly lit cardiac surgery.

This is a special report on the First People's Hospital by Kunming TV Station. In order to highlight the hard work and dedication of the medical staff, the special time in the early morning was specially chosen to shoot the program.

Generally speaking, most surgeries in hospitals are scheduled to be performed during the day.

Unless it is a critically ill patient who is transferred to another hospital and needs emergency surgery, it is usually late in the afternoon when they come here. After preoperative examination and preparation, most of the operations start at night.

If it was delivered later, it would have to be operated overnight in the early hours of the morning.

When the female reporter came to the Cardiac Surgery Department, she was mainly attracted by the brightly lit operating room.

There are no major operations in other departments tonight, only the operating room outside the heart has been lit for 24 hours.

"Wow, the operation being performed at 2 o'clock in the morning must be a very important major operation."

The female reporter turned the camera to the lounge and whispered: "Lying on the sofa is Dr. Yunfeng from the Great Vessel Medical Group. He is taking a nap with his eyes closed. It is said that he will have surgery soon, so we have to take advantage of this gap. Take a break and gather your mental strength."

"I heard from the nurse that his team has been in the hospital for a whole day and rescued 5 patients with type A aortic dissection on the operating table. This spirit of selfless dedication is truly commendable."

"The cardiac surgery team, from the director to everyone, has always personally interpreted the mission of dedicating to the cause of medicine and treating patients."

"They are the same as Dr. Yunfeng, seven days a week, there are always such days that they need surgery until two or three o'clock in the morning."

"Okay, after seeing their conscientious work attitude, let's take a look at their professional skills."

The camera changed, and the female reporter walked out of the lounge and came to the bright white corridor.

Suddenly, her voice was raised a bit, her breathing became rapid, and she couldn't hide her excitement.

"Audience, you must be very curious, where is the director in such a busy department?"

"In fact, we just got the news that Director Li of the Department of Cardiac Surgery is leading a professional team to carry out a thrilling major operation."

"This operation uses the technology called 'the top of the cardiac and great vessel surgery pyramid', and will complete the one-time replacement of all the aorta in a female patient."

"The patient was found to have a torn aorta, which spread to the main blood vessels next to it. The aorta in the chest cavity, abdominal cavity, and thigh was not only dissected, but also stretched, like a balloon that may burst at any time. Life is in danger."

"The only way is to replace the aorta of the whole body and replace it with artificial blood vessels."

"Aortic replacement surgery is a major cardiac surgery, which is very difficult, but the hospital has performed it many times, and the surgery has been very successful."

"However, unlike ordinary aortic replacement surgery, this time the patient needs to replace arteries throughout the body, including renal arteries, arteries of the lower extremities, almost a major exchange of blood from the heart to the thigh."

"In the words of the doctors, this is definitely the ceiling of the cardiac surgery world."

"You know, replacing the entire aorta at one time is equivalent to rebuilding a new channel covering the whole body for the human body."

"From the heart to the thigh, all blood vessels with a total length of nearly 1 meter must be replaced with artificial blood vessels."

"This is definitely the most difficult and most technical heart surgery ever performed. It is nothing short of a miracle."

"There is even more shocking news, that is, the artificial blood vessels replaced by patients are all from Sanqing Group, which is the first and only self-developed high-end artificial blood vessel in my country, and it is also the first clinical application .”

The more the female reporter spoke, the more excited she became, her entire face was filled with curiosity and shock.

"Next, let's go into the cardiac surgery operating room and watch this historic peak operation."

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