I can extract side effects

Kunming, First People's Hospital.

In the usually spacious operating room, the crowd is as dense as onion rings, clustering the operating table in the center.

The surgical directors occupy the C position next to the operating table, and the deputy directors squeeze into the most ample space nearby, and the attending doctors can only compete for the best view in front of the big screen.

After finally confirming their position, everyone's eyes were shining, and there was an expression of expectation on their faces.

On the operating table in the center, a patient in his 50s was lying in a deep coma, without any response to external stimuli.

This is a brain-dead patient who is dedicating the afterglow of his life to medical progress.

Next to him was an operating table, on which lay a piglet that had been anesthetized.

Since the patient's brain is dead, the body does not have any spontaneous reaction, and naturally does not need anesthesia, so the intraoperative and postoperative effects can be better observed.

The chief surgeon first came to Xiaozhu, skillfully cut open the lower back, took out a human kidney the size of a fist, then turned around and walked quickly to the patient.

The kidney was placed in a stainless steel container. Since it was only connected outside the body, it had not waited for full maturity, and its volume was a bit smaller.

Next, with the help of another surgeon, the two connected the patient's thigh and outer abdominal blood vessels to this small kidney.

The moment when the blood vessel clamp is released and the blood supply to the kidney is restored.

Everyone looked at the pink and tender kidney in front of them, and couldn't help cheering loudly.

The chief surgeon put a transparent protective cover on the container, and often let out a sigh of relief, announcing the successful conclusion of the operation.

"Very well, this kidney looks normal and has a good chance of success."

Director Cui stood next to the chief surgeon and said with relief.

"The next thing is to see how long it takes to urinate." As soon as Director Wu of the Department of Urology finished speaking, he heard a sound of fine water flowing.

Everyone turned their eyes to the urine bag, and found that almost instantly, a large pool of liquid flowed out from the urination tube.

"This... so fast." Someone exclaimed.

Before the others could speak, Director Wu shouted with ecstasy.

"Hurry up, take the excrement and test the creatinine content."

Everyone nodded when they heard the words. As long as the kidneys start to produce urine and excrete waste creatinine, this is a sign of good kidney function.

The nurse hastily removed the urine bag for testing.

The others stepped forward in turn, looked curiously at the external kidneys that were functioning normally under the transparent cover, and left one by one with excitement.

Everyone knows that as long as the implanted kidney is connected to the blood vessels of the human body, there is no immediate rejection, and the urine can be produced normally, the experiment is half successful.

Because if it is an unprocessed pig kidney, or a completely mismatched human kidney, if it is connected to a human body, it is impossible to survive for three hours, let alone three days.

If the speed is fast, the hyperacute rejection reaction will completely kill the organ within a few minutes.

Even if the transplant operation is really performed, it may not even take time for the skin to be sutured before you can see that the kidneys are starting to turn black.

And this kidney not only has a normal pink color, which is a sign of abundant blood supply, but it can even urinate immediately, which shows that there is no problem with its functionality. Once it is connected to the blood vessels, it is filtering the excretion of waste in the body.

Next, it depends on how long the patient can last.

Soon, the biochemical test results came out.

Creatinine was detected in the patient's urine.

In the following 3 days, the kidneys continued to work normally. Not only did the patient not experience rejection, but the creatinine and blood potassium levels in the body also dropped to normal levels.

This news finally made the doctors' hanging hearts completely relieved.

Because the effect was better than expected, the experiment time was extended to 72 hours.

During this time, the patient stayed in a separate ward in the ICU, and when the time came, the extracorporeal kidney was cleanly removed from the blood vessel.

The whole process went very smoothly, providing abundant data for subsequent clinical research.

The results were surprising, excluding hyperacute rejection and confirming the functionality of the implanted organ.

Although the data on acute rejection within 3 months and chronic rejection within half a year to 1 year is not yet available, all participants in the experiment are full of optimism about the future.

After all, the organ gap for transplant surgery is too great, and any breakthrough in this field can make people excited.

*****

Along with the medical world, the press is also excited.

The world's first implanted organ human transplant operation, although not transplanted into the body, but at least connected to the human body.

This is a huge breakthrough, absolutely eye-catching.

So the major media came after hearing the news, and after some interviews, the report was sent out overnight.

"Shocking! The human kidney grown in a pig has been transplanted into a human body for the first time!"

"Historic breakthrough in the field of organ transplantation, no longer have to worry about kidney failure."

"Sanqing led the Chinese medical community to make great achievements, sweeping away the lagging phenomenon in the field of organ transplantation in our country!"

Faced with such a shocking news, the Internet big Vs naturally retweeted it, scrambling for traffic.

A medical expert named Mars Garden published a long article expressing affectionate praise for Sanqing, which once detonated the entire Internet.

"Everyone may not know that the development of organ transplantation in my country is very backward. Due to the influence of traditional Confucian concepts, the concept of cardiopulmonary death is deeply rooted in the minds of Chinese people, which makes it difficult to promote brain death legislation."

"The introduction of brain death standards abroad is largely due to the promotion of organ transplants."

"Because it is difficult to transplant an organ after a person stops breathing for 15 minutes, the development of organ transplantation has always relied on the supply of organs from brain-dead patients to a large extent. It can be said that without the determination of brain death, there is no real human body. Organ transplant."

"There are currently more than 1.5 million uremia patients in my country, but only 5,000 kidney transplants can be performed each year. More than 1 million patients need liver transplants each year, but only about 10,000 patients can actually undergo surgery."

"Such a huge gap in organ transplantation is precisely due to the lack of legislation on brain death."

"However, brain death is actually a double-edged sword for organ transplantation. Many people worry that once the recognition of brain death is relaxed, a large number of ethical issues will arise, leading to the widespread practice of illegal organ transplantation."

"Just like euthanasia, brain death legislation is also a double problem of medical ethics and law."

"Fortunately, Sanqing has made new breakthroughs in the field of organ transplantation. In the future, patients who need organ transplants can directly obtain human organs from pigs, avoiding the pain of waiting."

"Such an achievement, in terms of saving lives and healing the wounded, is not too much for Wan Jiasheng Buddha."

"Let us look forward to the day when Sanqing's implanted organs enter the clinic!"

As soon as this article came out, it was reposted frantically, and it directly rushed to the top of the hot search.

Netizens discussed and expressed their opinions, which even caused quite a bit of controversy.

"I really didn't expect that the relationship between brain death and organ transplantation is so great."

"I always thought that when a person just died, the organs were the freshest and most suitable for transplantation, but that's not the case."

"Are you saying that brain death is real death? I don't think so. A relative of mine passed away after lying in the ward for more than half a year after brain death."

"Upstairs, did you confuse brain death with vegetative state, the two are completely different, okay?"

"There are more and more people donating organs now, which may relieve some of the pressure."

"I feel that I still can't let go of the brain death legislation. Who knows if it will be targeted by someone, and then something unexpected will happen."

"Stop conspiracy theories, as long as you don't donate your organs, you'll be fine."

"I'm an old piece of bacon anyway, so don't worry about someone staring at my organs."

"Didn't it mean that Sanqing has already researched using pigs to grow organs? Then you don't have to worry about being cut from the waist."

"Sanqing is amazing, and it can save many patients with organ failure and waiting for transplantation."

"My brother is suffering from uremia. He has been waiting in line for an organ at a young age. He has been waiting for 6 years, and he still doesn't know when he will be able to get it. I hope that Sanqing's technology will enter the clinic as soon as possible."

"I'm afraid it will take a long time. Judging from the news, none of them have been transplanted into the human body. They are just tested externally to see if they can be used. Compared with real organ transplants, the distance is still far away."

"Yeah, I thought it was inside the body too. If it's outside the body, it's not as good as Sanqing's artificial kidney, which is more practical and cheaper."

"Technology progress is a good thing. Experiments are carried out step by step. It is worth encouraging. Come on, Sanqing!"

"Yes, Qin destroyed the six countries one by one, take your time."

"I can foresee that the emergence of this technology in the future will definitely bring about some social problems. For example, protests from extreme animal protection activists and religious conservatives, some smear reports related to black industry interests, and social concerns about transplantation. Discrimination against people who grow organs from pigs, etc.”

"Fast forward to biopunk, reborn!"

"Only I care, is the meat of this gene-edited pig good?"

"So if I take the organs, can the other parts of the pig be taken home?"

"Upstairs, this kind of pig is specially bred. It is very different from ordinary pigs. It is best not to eat it. There are human cells in some parts. Although there are few, it is not without it."

"Damn it, it's so scary, I dare not eat it."

"If I were a religious person, I would not doubt the world."

"Humans and pigs are one, and the heavens are responsible for the pigs."

"There is a high probability that this technology will lead to terrible situations. DNA is a very magical substance. Is it really not afraid that pig DNA will enter the human body and be eaten back?"

"Uh, thinking too much, you eat pork every day, and you haven't seen that your DNA has turned into a pig?"

"The clones are ecstatic, there is a pig to die for themselves, and they are no longer afraid of cutting their kidneys."

"Yes, pigs don't smoke, drink, or eat junk food, and they are grown in a sterile laboratory. The kidneys grown on them are definitely healthier than my original kidneys that have been poisoned."

"In the past, when scientists studied pig kidney transplantation, I always felt that it was unreliable. Now that they have produced human kidneys, I feel that it is much more reliable."

*****

Kunming, Sanqing Headquarters.

The news of the successful operation naturally reached Wei Kang's ears immediately.

The extracorporeal dialysis can be maintained for three days. For him, the clinical trial has already taken the first step.

Although it is the first step in a hundred steps, it is enough to comfort people's hearts.

It seems that the next step of the brain-dead patient transplantation test can also start.

While contemplating, suddenly the mobile phone on the table rang.

As soon as it was connected, Wang Guiqing's familiar laughter came from inside.

"Mr. Wei, I heard that Sanqing's organ planting project has made great progress in clinical research. I'm really gratified."

Wei Kang couldn't help but wonder what the higher authorities think about the brain death legislation?

If internal organ transplants could be performed directly on brain-dead patients in China, he would not have to travel thousands of miles to Eagle Country to do so.

Thinking of this, he immediately asked: "Old Wang, I have a question I want to ask."

"We have now grown human organs in pigs, but clinical research has not been able to proceed smoothly."

"The difficulty lies mainly in the preclinical research. Xenotransplantation needs to go through an intermediate process, that is, to prove its effectiveness and safety in brain-dead patients before performing transplant operations on normal patients."

"However, the acceptance of brain death in our country is relatively low, let alone organ donation. Conspiracy theories are flying everywhere."

"Domestic organ transplantation research is also trapped in this, so it lags behind foreign countries. Now we in Sanqing have encountered the same problem. I wonder if there is any good way to solve the problem?"

Wang Guiqing's expression became solemn in an instant. In fact, he understood the meaning of the above, and he must fully support such an important experiment.

but--

Under the influence of Confucianism for thousands of years, most Chinese people can only accept the view of heart and lung death.

Not to mention, brain death is closely linked to organ transplantation.

Many people may seem to be very open-minded, and they do not oppose organ transplants, but respect blessings very much.

But when it comes to him, the laws of his ancestors are immutable, and he absolutely has to be buried in the ground with his whole body. Even cremation is difficult to accept.

If legislation on brain death is introduced rashly, it will inevitably cause a huge shock and shock to the entire society.

Wang Guiqing pondered for a moment, then said slowly.

"Mr. Wei, I understand your thoughts very well, but we must also consider that the overall cultural level of our people is not high. It may be difficult to popularize and implement the brain death standard nationwide, and it may even arouse everyone's resentment. "

"On the other hand, even if the patient is brain-dead, family members may not be able to accept organ donation, so we still have to think long-term."

"However, in a small area, under certain circumstances, it can be implemented."

"Small scope and specific circumstances? What does this mean?" Wei Kang asked puzzled.

"For those who have signed an organ donation agreement, if they experience brain death, they can make a special case and use the criteria for judging brain death, so they don't have to wait until they die completely before donating."

Wang Guiqing explained: "This is also a flexible application of policies and regulations, and a strong support for clinical medical technology."

"what do you think?"

"This..." Wei Kang suddenly understood.

After all, it still depends on public opinion. If the patient is voluntary, it is naturally excellent. If he is not voluntary, he must not coerce public opinion.

This condition seems to open the door to convenience, but it is necessary to donate organs and brain death at the same time. Such patients are not so easy to find.

After waiting for ten days and a half months, I don't know if there is a case.

It's not as convenient as it is in foreign countries. After the legislation of brain death, organ transplantation is extremely developed. As long as you spend enough money, you can find enough donors.

However, he also knew in his heart that this was done for everyone's benefit, and if he could do something special, it was considered his full support.

Wei Kang smiled and said, "Then I would like to thank Mr. Wang for his kindness."

After chatting casually for a few more words, they hung up the phone.

He looked at the news that was pushed, and found that this matter had already made a lot of noise on the Internet, so he clicked in casually.

Netizens were chatting enthusiastically, expressing appreciation in their tone, and even many family members of patients waiting for organ transplants complained.

Looking at it, a crazy idea suddenly flashed in Wei Kang's mind.

"Since everyone is so optimistic, I hope that Sanqing will make a breakthrough in organ planting as soon as possible."

"Clinical research needs the support of brain-dead patients and their families to proceed smoothly."

"Then why don't I just ask the general public to see what they really think?"

"This is a major event that benefits all citizens, so it is natural to ask for their opinions."

"If you encounter difficulties, you should also seek their help."

"If they all think it's not good, then I can only do overseas clinical work first."

"If there are enough people who support Sanqing, then, in the vast crowd, maybe I will be able to find willing patients."

"For the country and the people, for the people and for me, no matter how you look at it, this wave is not a loss!"

Once this thought popped up, I couldn't hold it back anymore.

With excitement, Wei Kang quickly typed a paragraph and posted it on Langbo's personal account.

In an instant, there was an uproar.